Category Biology/Biotechnology

New role for Insulin: Studies tie the hormone to brain’s ‘Pleasure’ Center

Image of a rodent brain cell, with insulin receptors (seen as many green dots) that when activated spur release of dopamine (In background in pink is neuron nucleus.) Credit: Courtesy of Nature Communications

Image of a rodent brain cell, with insulin receptors (seen as many green dots) that when activated spur release of dopamine (In background in pink is neuron nucleus.) Credit: Courtesy of Nature Communications

Insulin, essential for controlling blood sugar levels and feeling of being full after eating, plays a much stronger role than previously known in regulating release of dopamine, a neurotransmitter that helps control the brain’s reward and pleasure centers, new studies by researchers at NYU Langone Medical Center show.

“We found that when there’s more insulin in the brain, there will be more dopamine released, not less,” says study senior investigator and NYU Langone neuroscientist Margaret Rice, PhD...

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Seeing Sound: Blind people could acquire a new Sensory Functionality Similar to Vision

Depiction of the vOICe encoding scheme. A camera mounted on glasses records video that is converted to sound by a computer and transmitted to headphones in real time. Credit: Shimojo Lab/Caltech

Depiction of the vOICe encoding scheme. A camera mounted on glasses records video that is converted to sound by a computer and transmitted to headphones in real time. Credit: Shimojo Lab/Caltech

Caltech researchers have now discovered that intrinsic neural connections- crossmodal mappings -can be used by assistive devices to help the blind detect their environment without requiring intense concentration or hundreds of hours of training. This new multisensory perspective on such aids (called sensory substitution devices) could make tasks that were previously attention-consuming much easier, allowing nonsighted people to acquire a new sensory functionality similar to vision.

“.. 99% of our daily life depends on multisensory- also called multimodal processing...

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High-fat diet may cause changes in brain that lead to anxiety, depression


High-fat-diet-could-cause-brain-changes-that-lead-to-anxiety-and-depression-Mouse-data

A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.

Also, the beneficial effects of an antidepressant were blunted in mice fed a high-fat diet. “When treating depression, in general there is no predictor of treatment resistance,” said Dr. Bruno Guiard, senior author of the British Journal of Pharmacology study. “So if we consider metabolic disorders as a putative treatment resistance predictor, this should encourage psychiatrists to put in place a personalized treatment with antidepressant drugs that do not further destabilize metabolism.”

On the other hand, taking mice off a high-fat diet completely reversed the animals’ metabolic impairments ...

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Scientists have Decoded a Central Signal Cascade associated with Epileptic Seizures

Fluorescence in the brain of a living mouse: The emanating beams of light can be measured through the top of the skulls. The degree of fluorescence is reflected through colors, whereby the intensity decreases from red to violet. Credit: © ???Image: Karen von Loo/Laboratory of Albert Becker

Fluorescence in the brain of a living mouse: The emanating beams of light can be measured through the top of the skulls. The degree of fluorescence is reflected through colors, whereby the intensity decreases from red to violet. Credit: © Image: Karen von Loo/Laboratory of Albert Becker

If they blocked a central switch in epileptic mice, the frequency and severity of the seizures decreased. Using a novel technology, it was possible to observe the processes prior to the occurrence of epileptic seizures in living animals. About 1 of 20 people in the course of his or her life suffers an epileptic attack, during which the nerve cells get out of their usual rhythm and fire in a very rapid frequency. This results in seizures...

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