Category Biology/Biotechnology

How does your microbiome grow?

Bacterial growth rates computed with the new method are shown (top, average; bottom, for specific species, red represents faster replication) for a human subject that underwent a radical dietary change. Compared are days in which only white boiled rice was consumed (grey area) and days of normal diet (white area). A global change in bacterial growth dynamics was observed between dietary regimens. Credit: Weizmann Institute of Science

Bacterial growth rates computed with the new method are shown (top, average; bottom, for specific species, red represents faster replication) for a human subject that underwent a radical dietary change. Compared are days in which only white boiled rice was consumed (grey area) and days of normal diet (white area). A global change in bacterial growth dynamics was observed between dietary regimens. Credit: Weizmann Institute of Science

The reproduction rates of the bacteria in one’s gut may be a good indicator of health or disease, scientists say. In their examination of human microbiome data, the research group found that particular changes in bacterial growth rates are uniquely associated with type II diabetes; others are tied to inflammatory bowel disease, for example.
The study began w...

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Wild Blueberry Extract could help Prevent Dental Plaque Formation

 

A blueberry extract could lead to a new therapy for periodontitis and a reduced need for antibiotics. Many people have had some degree of gum inflammation, or gingivitis, caused by dental plaque. The gums get red and swollen, and they bleed easily. If left unchecked, the condition can progress to periodontitis. The plaque hardens into tartar, and the infection can spread below the gum line and destroy the tissue supporting the teeth. To treat this condition, dentists scrape off the tartar and sometimes have to resort to conventional antibiotics. But recently, researchers have started looking at natural antibacterial compounds to treat gum disease...

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Silk Bio-ink could help advance Tissue Engineering with 3D Printers

Scientists have developed a silk-based, 3-D printer ink for use in biomedical implants or tissue engineering. Credit: American Chemical Society

Scientists have developed a silk-based, 3-D printer ink for use in biomedical implants or tissue engineering. Credit: American Chemical Society

Silk bio-ink is useful for more complex tissues with versatile functions eg tissues that can be loaded with pharmaceuticals. In the past finding an ideal bio-ink has stalled more complicated tissue engineering progress till now. Most inks currently being developed for 3D printing are made of thermoplastics, silicones, collagen and gelatin or alginate. But there are limits to how these inks can be used. For example, the temperatures, pH changes and crosslinking methods that may be required to toughen some of these materials can damage cells or other biological components that researchers want to add to the inks.

Silk-based bioinks were developed for 2D and 3D printing. By incorporating nontoxic polyols into silk solutions, two-part formulations with self-curing features at room temperature were generated. By varying the formulations the crystallinity of the silk polymer matrix could be controlled to support printing in 2D and 3D formats interfaced with CAD geometry and with good feature resolution. The self-curing phenomenon was tuned and exploited in order to demonstrate the formation of both structural and support materials.

Silk-based bioinks were developed for...

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Completely Paralyzed Man Voluntarily Moves his Legs

Courtesy of Mark Pollock Mark Pollock and trainer Simon O’Donnell

Mark Pollock and trainer Simon O’Donnell Courtesy of Mark Pollock

Robotic step training, noninvasive spinal stimulation enable patient to take thousands of steps. A 39yo man who had had been completely paralyzed for 4 years was able to voluntarily control his leg muscles and take many steps in a robotic exoskeleton during 5 days of training with the aid of the robotic device combined with a novel noninvasive spinal stimulation pattern that does not require surgery, UCLA scientists report.

This is the first time that a person with chronic, complete paralysis has regained enough voluntary control to actively work with a robotic device designed to enhance mobility...

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