Category Chemistry/Nanotechnology

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.

Scientists have revealed how a genetic switch involved in the packaging of DNA may be key to a cancer cell’s ability to keep growing.The Francis Crick Institute researchers found that production of a protein called H1.0 was frequently switched off in many cancer types and that reactivating this protein halted tumour growth. Studying cancer cells lacking H1.0, they found that DNA becomes uncoiled at key points, activating a series of genes that stall the cell in an ‘immature’ state. This allows the cells to carry on dividing and expanding the tumour.

But as the tumour grows H1.0 can spontaneously become switched back on in some cells...

To make the superstructure, the nanocrystals are dissolved in an oleaginous fluid that floats on a layer of coolant. As the oil evaporates, the nanocrystals appear to form a neat hexagonal structure on the surface of the water. Credit: Image courtesy of Utrecht University

Two years ago, a team led by Utrecht University in Science explaining how they had created a material with unique and extremely interesting electronic characteristics. In this ‘supercrystal’, the electrons move almost with the speed of photons, and the electric current can be switched on and off. This makes it ideal for ultra-fast electronics. But at the time, the researchers were at a loss to explain how this ‘supercrystal’ obtained its unique structure...

Schematic illustration and chemical structure of semi-printed plastic solar cells in air, using food additive o-MA as solvent. Credit: Long Ye, NC State

Researchers have created an efficient, semi-printed plastic solar cell without environmentally hazardous halogen solvents. These solar cells can be manufactured at room temperature, which has implications for large-scale commercial production. Plastic solar cells, or organic photovoltaics, are popular because they are lightweight, flexible, transparent and inexpensive to manufacture, making them useful in multiple applications. Unfortunately, the halogen-containing solvents used in their manufacture are an obstacle to large-scale commercialization...