Category Chemistry/Nanotechnology

BTI Professor Daniel Klessig and lab members Research Associate Hyong Woo Choi and Postdoctoral scientist Murli Manohar.

Aspirin’s active form, salicylic acid, blocks a protein called HMGB1, which triggers inflammation in damaged tissues. The new findings may explain the disease-preventing effects of a low-dose aspirin regimen and offer hope that more effective aspirin-like drugs may be developed for a wide variety of diseases.

“We’ve identified what we believe is a key target of aspirin’s active form in the body, salicylic acid, which is responsible for some of the many therapeutic effects that aspirin has...

Murphy et al. describe a novel pseudokinase architecture from human TRIB1 and characterize its substrate-recognition motif within the C/EBPα transcription factor. Combined with biophysical studies, this shows how Tribbles proteins eschew catalytic activity in favor of function as signaling scaffolds.

Protein Trib1 plays a vital role in controlling how and when other proteins are degraded, which is essential for managing protein levels in the cell. The finding could be used to develop new drugs to treat cancers such as leukaemia, caused by malfunctioning of the Trib1 protein.

Trib1 is part of the protein family Tribbles, which play diverse roles in cell signalling and development. Tribbles are named after the small, furry creatures from Star Trek that reproduce uncontrollably...

Lightweight and high-power density capacitors are of particular interest for the development of hybrid and electric vehicles. The fast-charging devices allow for significant energy saving, because they can accumulate energy during braking and release it during acceleration. Credit: Xuan Yang and Kevin Yager

New work demonstrates an improved 3D energy storage device constructed by trapping functional nanoparticles within the walls of a foam-like structure made of nanocellulose. The foam is made in one step and can be used to produce more sustainable capacitor devices with higher power density and faster charging abilities compared to rechargeable batteries...

The discovery opens up the possibilities to use carbon in more powerful batteries, driving down the costs of portable power. Lithium ion batteries power many devices, from smartphones and digital cameras all the way up to cars and even aircraft. The batteries work by having 2 electrically charged materials suspended in a liquid to produce a current. Carbon is used as one of those materials in smaller batteries, but for bigger, more powerful batteries – such as those used in electric cars – carbon is not suitable because of its structure, which cannot produce the required current density.

Collecting candle soot from the (a) tip of the flame and (b) middle of the flame. SS current collector (c) before and (d) after deposition of carbon soot.

Dr. Chandra Sharma and Dr...