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    Researchers use Artificial Intelligence to Predict Cardiovascular Disease

    February 28, 2023, Categories  Health/Medical, Biology/Biotechnology

    Researchers use artificial intelligence to predict cardiovascular disease
    Study design, workflow, and bioinformatics. Overall research methodology includes, (1) clinical data analysis; (2) cohort building; (3) cardiovascular disease-based sample collection; (4) sample management and tracking; (5) RNA extraction, and high-throughput sequencing; (6) pipeline and bioinformatics application development for RNA-seq data processing, quality checking, gene-disease annotation, and phenotyping; and (7) implementation of artificial intelligence and machine learning techniques for predictive analysis. Credit: Genomics (2023). DOI: 10.1016/j.ygeno.2023.110584

    Researchers may be able to predict cardiovascular disease — such as arterial fibrillation and heart failure — in patients by using artificial intelligence (AI) to examine the genes in their DNA, according to a new ...

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    Impact of Key Alzheimer’s Protein depends on type of Brain Cell in which it is produced

    February 24, 2023, Categories  Health/Medical, Biology/Biotechnology

    Scientists Yadong Huang and Nicole Koutsodendris looking at a monitor in the lab at Gladstone Institutes
    Yadong Huang and his team demonstrated in mice that the ApoE4 protein from neurons plays a much bigger disease-driving role in Alzheimer’s than previously thought.

    Of all the known genetic risk factors for late-onset Alzheimer’s disease, the strongest is a gene for the protein called ApoE4. People with one copy of this gene are 3.5 times more likely, on average, to develop Alzheimer’s than others, and those with two copies face a 12-fold increased risk. However, exactly how ApoE4 boosts the risk of Alzheimer’s remains unclear.

    Multiple types of cells in the brain make ApoE4—some of it is produced by neurons, but other brain cells called glia make it in higher quantities. For that reason, most prior research on this protein has focused on ApoE4 from glia.

    Now, researchers at G...

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    Large study finds that Air Pollution Speeds Bone Loss from Osteoporosis

    February 22, 2023, Categories  Health/Medical, Biology/Biotechnology

    Air Pollution Speeds Bone Loss from Osteoporosis: Large Study
    Bayesian kernel machine regression univariate exposure-response plots with 95% credible intervals for the effect of each pollutant on the different bone mineral density sites evaluated. Credit: eClinicalMedicine (2023). DOI: 10.1016/j.eclinm.2023.101864

    Elevated levels of air pollutants are associated with bone damage among postmenopausal women, according to new research led by scientists at Columbia University Mailman School of Public Health. The effects were most evident on the lumbar spine, with nitrous oxides twice as damaging to the area as in normal aging.

    The research findings appear in the journal eClinicalMedicine.

    Previous studies on individual pollutants have suggested adverse effects on bone mineral density, osteoporosis risk, and fractures in older individuals...

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    Scientists make Stunning Discovery, find New Protein Activity in Telomeres

    February 21, 2023, Categories  Health/Medical, Biology/Biotechnology

    Newly discovered telomeric protein VR, (green spheres) is seen accumulating in nuclei (blue ovals) in human osteosarcoma cancer cells stained in red. (Griffith Lab)

    Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes seem to hold a potent biological function that’s potentially relevant to our understanding of cancer and aging.

    Reporting in the Proceedings of the National Academy of Sciences, UNC School of Medicine researchers Taghreed Al-Turki, Ph.D., and Jack Griffith, Ph.D...

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