Category Health/Medical

Brain Discovery holds key to Boosting Body’s Ability to Fight Alzheimer’s, MS

John Lukens, PhD, is investigating how brain injury disrupts drainage of deleterious waste from the brain and how that may contribute to Alzheimer's disease.
John Lukens, PhD, is leading important research that could transform how we approach Alzheimer’s and other neurological diseases.

UVA Health researchers have discovered a molecule in the brain responsible for orchestrating the immune system’s responses to Alzheimer’s disease and multiple sclerosis (MS), potentially allowing doctors to supercharge the body’s ability to fight those and other devastating neurological diseases.

The molecule the researchers identified, called a kinase, is crucial to both removing plaque buildup associated with Alzheimer’s and preventing the debris buildup that causes MS, the researchers found. It does this, the researchers showed, by directing the activity of brain cleaners called microglia...

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Flatworm-Inspired Medical Adhesives Stop Blood Loss

Design of LIMB. a Schematic illustration of marine organisms that contain interconnected micropores for adhesiveness and transport of liquid reagents. b Schematic of LIMB adhering on blood-exposed substrates. c Schematics showing that LIMB can uptake interfacial fluid, secrete functional liquids, and coagulate blood, thereby providing adhesion, hemostatic, and sealing function. d Confocal image of rhodamine-labeled LIMB (red) containing micropores, partially filled with a FITC-labeled chitosan functional liquid (green). e Sizes of surface and internal pores in LIMB containing 2 M or 5 M PAAm. f–h Stress-stretch curves (f), fracture energy (g), and fractocohesive lengths (h) of LIMBs with varying PAAm content. Values in egh represent the mean ± s.d. (n = 40 for 2M-LIMB Surfa...
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Clusters of Genes help Mice Live Longer

Genetic analyses in UM-HET3 mice used in the Interventions Testing Program highlight sex- and
age-specific longevity loci. Body weight associates with longevity, as does litter size, through its effect on
body weight. Mendelian randomization in humans recapitulated these relationships between early growth
and life span. Gene expression analyses, cross-species integration, and Caenorhabditis elegans life-span
experiments highlight candidate longevity genes and provide a resource for further investigation.

Researchers from the National Institute on Aging (NIA)-funded Interventions Testing Program recently reported the discovery of multiple candidate genes that influence longevity...

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Powerful Enzyme that Tamps Down Inflammation Holds Promise for Protecting the Eyes in Diabetes, Premature Birth

Drs. Ruth and William Caldwell

An enzyme under study to treat certain cancers is also showing promise in reducing the significant vision damage that can result from diabetes and premature birth, scientists report.

Inflammation is considered a hallmark of cancer. It’s pervasive as well in both of these potentially blinding eye conditions, in which inadequate oxygen to the eyes prompts growth of new blood vessels to better deliver oxygen, but which instead often obstruct the vision pathway and become leaky, which causes swelling, further hindering vision.

Scientists at the Medical College of Georgia report in newly published studies in the journals Cell Death and Disease and Cells, increasing evidence that making more of the enzyme arginase 1, or A1, available helps alleviate these...

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