Category Health/Medical

Family ties: Inherited Genetic Variants Increase Risk of Hodgkin Lymphoma

(L to R) Ninad Oak Ph.D., Jamie Flerlage M.D., Jason Myers, and Evadnie Rampersaud, Ph.D. Not pictured: Jun J. Yang Ph.D. and Jamie Maciaszek Ph.D.

Why did my child get cancer? Clinicians have longed for a way to help answer this question. Doctors knew Hodgkin lymphoma sometimes occurs in families, but why this happens has been a mystery. Scientists at St. Jude Children’s Research Hospital have now helped solve it. The researchers studied multiple families affected by Hodgkin lymphoma and identified genetic variants linked to an increased risk of developing the disease. The findings appeared as a first edition in Blood.

Hodgkin lymphoma is a cancer of the lymphatic system (part of the immune system) that affects lymph nodes but can spread to the spleen, liver, bone marrow and lungs...

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Cooling away the pain: Researchers develop Bioresorbable, Implantable device to Block Pain Signals from Peripheral Nerves

Opioid use is highly effective for pain management but is associated with high rates of addiction and deaths due to overdose. Now, an international team of researchers has developed a soft, bioresorbable, implantable device which can provide a cooling effect to peripheral nerves, leading to blocking of pain signals. The device demonstrated high precision and efficacy in rat models with spared nerve injuries and can serve as an effective substitute for opioids.

Owing to their high efficacy, opioids are used widely for the management of neuropathic pain, despite the increasing rates of opioid addiction and deaths due to overdose. To avoid these side effects, there is an urgent need for pain management approaches that can substitute opioid use.

It is well known that cold temperatur...

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How the Gut may help to Drive COVID-19

New findings from Flinders University have demonstrated a molecular link between COVID-19 and serotonin cells in the gut.

The research could help provide further clues to what could be driving COVID-19 infection and disease severity and supports previous evidence that antidepressants, known as selective serotonin reuptake inhibitors (SSRIs), could reduce the severity of COVID symptoms.

COVID-19 displays an array of symptoms, which can regularly include gastrointestinal issues such as diarrhoea. Recent research has indicated that these gut symptoms in COVID-19 patients worsen with the severity of the disease, and this is linked to heightened gut-derived serotonin, released to cause gut dysfunction, increasing the body’s immune response and potentially worsening patient outcomes.

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Having High Cholesterol and Reduced Physical Stamina and being Overweight are Long COVID Sequelae in Young Adults

Having high cholesterol and reduced physical stamina and being overweight are long COVID sequelae in young adults
Test battery used in the Long COVID in Military Organizations study. The test battery was used to evaluate the long-term sequelae of COVID-19 in young adults. A variety of quantitative tests and standardized questionnaires were used to measure the effect on various organ systems and parameters in participants following COVID-19, asymptomatic SARS-CoV-2 infection, or in individuals who were non-exposed to SARS-CoV-2. Anti-N=anti-SARS-CoV-2 nucleocapsid. Anti-S=anti-SARS-CoV-2 spike. BDI-13=Beck Depression Inventory (13 items). CFQ-11=Chalder Fatigue Scale. eGFR=estimated glomerular filtration rate. FeNO=fractional exhaled nitric oxide. FSH=follicle stimulating hormone. HbA1c=glycated hemoglobin. IES-R=Impact of Event Scale-Revised. LH=luteinising hormone...
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