Category Health/Medical

New Patent-Pending method Mass-produces Antitumor cells to Treat Blood Diseases and Cancer

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Xiaoping Bao, a Purdue University assistant professor from the Davidson School of Chemical Engineering, has improved upon traditional methods to create human immune cells from human pluripotent stem cells. The research was published in the peer-reviewed journal Cell Reports. (Syahrir Maulana/iStock photo)

A Purdue University chemical engineer has improved upon traditional methods to produce off-the-shelf human immune cells that show strong antitumor activity, according to a paper published in the peer-reviewed journal Cell Reports.

Xiaoping Bao, a Purdue University assistant professor from the Davidson School of Chemical Engineering, said CAR-neutrophils, or chimeric antigen receptor neutrophils, and engraftable HSCs, or hematopoietic stem cells, are effective types of therapies for...

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Flare-ups of Gout are linked to Heart Attack and Stroke

Gout

Experts at the University of Nottingham, in collaboration with experts at Keele University, have found that the risk of heart attacks and strokes temporarily increases in the four months after a gout flare.

The research showed that gout patients who suffered from a heart attack or stroke were twice as likely to have had a gout flare in the 60 days prior to the event, and one and a half times more likely to have a gout flare in the 61-120 days prior.

The results of the study, led by Professor Abhishek in the School of Medicine at the University of Nottingham, are published in the journal JAMA.

Gout is a common form of arthritis that affects one in 40 adults in the UK...

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Using Light to Restore Cell Function

A super resolution image captured in Diao’s lab shows the endoplasmic reticulum in green, lysosomes in pink and mitochondria in red. Using the light-activated proteins, the mitochondria and lysosomes are brought together to conduct mitochondrial fission. Photo provided by Jiajie Diao.

New research from the University of Cincinnati shows early indications that light can be used as a treatment for certain diseases, including cancer.

Researchers from UC, the U222niversity of Illinois Urbana-Champaign and the University at Buffalo published the results of their study demonstrating light-activated proteins can help normalize dysfunction within cells in the journal Nature Communications July 25.

The research centers on the functions of mitochondria, organelles within a cell that act as...

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Fast-acting Immune Cells provide Powerful Protection against Stroke

CREDIT: Adapted from Cai and Shi et al., 2022
CAPTION:  Within 24 hours after researchers depleted CD8+TRLs from the bloodstream of stroke mice, the size of the brain region affected by ischemia expanded by 50% (middle panel) compared to animals whose CD8+TRL levels remained intact (left and right panels).

CD8+ regulatory-like Tcells reach the brain within 24 hours after stroke onset, where they release molecules that provide direct neuroprotective effects, as well as limit inflammation and secondary brain damage.

“The beauty of CD8+TRLs is in their fast response. They confer very potent protection to the brain, which can last a long time,” said co-corresponding author Xiaoming Hu, M.D., Ph.D., associate professor of neurology at Pitt and a U.S...

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