Category Health/Medical

McMaster University researchers have found not only how some viral infections cause severe tissue damage, but also how to reduce that damage.

They have discovered how Type I interferon (IFN) stops the immune system from “going rogue” and attacking the body’s own tissues when fighting viral infections, including COVID-19.

Their paper was published in the journal PLOS Pathogens.

Senior author Ali Ashkar said IFN is a well-known anti-viral signaling molecule, that when released by the body’s cells, can trigger a powerful immune response against harmful viruses.

“What we have found is that it is also critical to stop white blood cells from releasing protease enzymes, which can damage organ tissue...

We humans lose mental acuity, an unfortunate side effect of aging. And for individuals with neurodegenerative conditions such as Alzheimer’s and Parkinson’s, the loss of cognitive function often accompanied by mood disorders such as anxiety is a harrowing experience. One way to push back against cognitive decline and anxiety would be to spur the creation of new neurons. For the first time, University of North Carolina School of Medicine scientists have targeted a specific kind of neuron in mice to increase the production of neural stem cells and spur on the creation of new adult neurons to affect behavior.

Targeting these cells, as reported in the journal Nature Neuroscience, modulated memory retrieval and altered anxiety-like behaviors in mice...

Ovarian cancer kills 14,000 women in the United States every year...

Research from the University of Michigan Rogel Cancer Center could provide a new approach to treating an aggressive form of breast cancer.

A study led by Duxin Sun, Ph.D., found that targeting the immune microenvironment in lymph nodes and tumors simultaneously led to long-term tumor remission in mice models of metastatic triple negative breast cancer. Further, using nanoparticles to deliver these immune-altering drugs increases treatment efficacy. These results appear in Science Translational Medicine.

Immunotherapy combined with chemotherapy has been long approved as standard treatment option for triple negative breast cancer but only shows a limited response in patients...