Category Health/Medical

Surprising Culprit Worsens Stroke, TBI damage

In the aftermath of a stroke or traumatic brain injury (TBI), a group of amino acids that typically support brain function contribute significantly to the brain destruction that can follow both these injuries, scientists report.

The new study provides for the first time the surprising evidence that four common nonexcitatory amino acids that usually make proteins which are essential to brain function, instead cause irreversible, destructive swelling of both the astrocytes that support neurons and the neurons themselves, says Dr. Sergei Kirov, neuroscientist in the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia.

“There are many ways to kill neurons...

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People with Similar Faces likely have Similar DNA

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Highlights
•Facial recognition algorithms identify “look-alike” humans for multiomics studies
•Intrapair look-alikes share common genetic sequences such as face trait variants
•DNA methylation and microbiome profiles only contribute modestly to human likeness
•The identified SNPs impact physical and behavioral phenotypes beyond facial features

A collection of photos of genetically unrelated lookalikes, along with DNA analysis, revealed that strong facial similarity is associated with shared genetic variants. The work appears August 23rd in the journal Cell Reports.

“Our study provides a rare insight into human likeness by showing that people with extreme lookalike faces share common genotypes, whereas they are discordant at the epigenome and microbiome levels,” says senior a...

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Researchers identify the Target of Immune Attacks on Liver Cells in Metabolic Disorders

illustration of human liver anatomy
Illustration of human liver anatomy. Credit: Shutterstock

When fat accumulates in the liver, the immune system may assault the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that trips these defenses, a discovery that helps to explain the dynamics underlying liver damage that can accompany type 2 diabetes and obesity.

In a study published Aug. 19 in Science Immunology, researchers mimicked these human metabolic diseases by genetically altering mice or feeding them a high-fat, high-sugar diet. They then examined changes within the arm of the rodent’s immune system that mounts defenses tailored to specific threats...

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New Research Model illuminates How Organs Communicate with each other

A novel mouse model for mapping protein communication between organs. Proteins are labeled by biotin and their movement in the body can be tracked. Credit: Scripps Research and University of Southern California

Researchers uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity. Our many different organ systems are in constant communication with each other. During exercise, for example, muscles send out signals to fat and liver tissue to release their energy sources. While these communication networks play a critical role in our bodies every day, it has been historically difficult to uncover such pathways...

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