Category Health/Medical

Scientists Characterize the Imbalanced Gut Bacteria of Patients with Myocardial Infarction, Angina and Heart Failure

In two publications in Nature Medicine, a European-Israeli team of researchers show how major disturbances occur in the gut microbiome of patients suffering from heart disease. Given this latest evidence from microbiome research, one of the senior lead researchers, Professor Oluf Pedersen from the University of Copenhagen, calls for stronger and more focused public health initiatives to prevent or delay these common diseases that are a leading cause of premature death worldwide through plant-based and energy-controlled diet, avoidance of smoking and compliance with daily exercise.

The human gut contains trillions of bacteria, collectively called the gut microbiome, which may have positive and negative effects on human health...

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Astronomers discover Widest Separation of Brown Dwarf Pair to date

AN ARTIST’S RENDITION OF A BINARY SYSTEM OF BROWN DWARFS LIKE CWISE J014611.20-050850.0AB.
Credit: William Pendrill

A team of astronomers has discovered a rare pair of brown dwarfs that has the widest separation of any brown dwarf binary system found to date. “Because of their small size, brown dwarf binary systems are usually very close together,” said Emma Softich, an undergraduate astrophysics student at the Arizona State University (ASU) School of Earth and Space Exploration and lead author of the study. “Finding such a widely separated pair is very exciting.”

The gravitational force between a pair of brown dwarfs is lower than for a pair of stars with the same separation, so wide brown dwarf binaries are more likely to break up over time, making this pair of brown dwarfs an ex...

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Molecular ‘Xulprit’ caught driving Cell Death and Inflammation

Highlights
•IFNγ and TLR signaling causes cell death via caspase-8, iNOS, and BAX/BAK
•Caspase-8 regulates BCL2 and iNOS expression to activate BAX/BAK independent of BID
•iNOS causes caspase-8 cleavage and destabilizes the BAX/BAK inhibitors MCL1 and A1
•Caspase-8 and iNOS promote severe disease upon SARS-CoV-2 infection of mice

A WEHI-led study has identified a molecular ‘culprit’ responsible for causing damaging levels of cell death and inflammation in the body. The findings could lead to improved treatment options for a range of conditions driven by inflammatory cell death, including the SARS-CoV-2 virus.

Cell death is an important part of the body’s immune response to infection...

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How Fat Cells in the Skin help Fight Acne

Microscopic image of an inflamed pimple with cathelicidin stained red, fat cells stained green and the nuclei of every cell stained blue. Because cathelicidin is produced from fat cells, their staining merges together.

Researchers have discovered a specific antimicrobial skin cell and the role it plays in acne development, which could result in more targeted treatment options. Acne is among the most common skin diseases in the United States, according to the American Academy of Dermatology Association, affecting up to 50 million Americans each year. It is also among the least studied.

It’s known that hair follicles assist in the development of a pimple, but new research suggests the skin cells outside of these hair follicles play a larger role...

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