Category Health/Medical

Magnesium is essential for the Immune System, including in the Fight Against Cancer

Immunofluorescence microscopy: T cells (blue) attack cancer cells (gray) by binding to them via their surface protein LFA-1. LFA-1 needs magnesium to adopt an active, elongated form (active LFA-1 in red). (Image: J. Lötscher et al., Cell, 2022)

The level of magnesium in the blood is an important factor in the immune system’s ability to tackle pathogens and cancer cells. Writing in the journal Cell, researchers from the University of Basel and University Hospital Basel have reported that T cells need a sufficient quantity of magnesium in order to operate efficiently. Their findings may have important implications for cancer patients.

Magnesium deficiency is associated with a variety of diseases, such as infections and cancer...

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Research Team identifies New Mechanism for Protecting DNA

Discovery offers hope to better understand how diseases like cancer, premature aging can be prevented. Researchers from Case Western Reserve University have identified a new mechanism by which a protein known for repairing damaged DNA also protects the integrity of DNA by preserving its structural shape.

The discovery, involving the protein 53BP1, offers insight into understanding how cells maintain the integrity of DNA in the nucleus, which is critical for preventing diseases like premature aging and cancer.

A research team led by Youwei Zhang, an associate professor of pharmacology at the Case Western Reserve School of Medicine and a member of the Molecular Oncology Program at the Case Comprehensive Cancer Center, conducted the study. The findings were published (Jan...

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Machine Learning Model uses Blood Tests to predict COVID-19 survival

Proteomics core facility at Charité University hospital Berlin. Credit: Johannes Hartl, Charité

A single blood sample from a critically ill COVID-19 patient can be analyzed by a machine learning model which uses blood plasma proteins to predict survival, weeks before the outcome, according to a new study published this week in the open-access journal PLOS Digital Health by Florian Kurth and Markus Ralser of the Charité—Universitätsmedizin Berlin, Germany, and colleagues.

Healthcare systems around the world are struggling to accommodate high numbers of severely ill COVID-19 patients who need special medical attention, especially if they are identified as being at high risk...

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Scientists uncover ‘Resistance Gene’ in deadly E. coli

An artist’s impression of E. coli, which infects over 150 million people worldwide.

Scientists have pinpointed a gene that helps deadly E. coli bacteria evade antibiotics, potentially leading to better treatments for millions of people worldwide.

The University of Queensland-led study found a particular form of the bacteria — E. coli ST131 — had a previously unnoticed gene that made it highly resistant to commonly prescribed antibiotics.

Professor Mark Schembri, from UQ’s School of Chemistry and Molecular Biosciences, said this ‘resistance gene’ can spread incredibly quickly.

“Unlike gene transfer in humans, where sex is required to transfer genes, bacteria have genetic structures in their cells — called plasmids — that are traded quickly and easily between each other,” Profes...

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