Category Health/Medical

Key to Resilient Energy-efficient AI/machine learning may reside in Human Brain

Synchronization of neural oscillations achieved by astrocytes
Synchronization of neural oscillations is achieved by astrocytes through information sharing among their glial network. Credit: Elizabeth Floresgomez Murray. All Rights Reserved.

A clearer understanding of how a type of brain cell, astrocytes function and can be emulated in the physics of hardware devices, may result in artificial intelligence (AI) and machine learning that autonomously self-repairs and consumes much less energy than the technologies currently do, according to a team of Penn State researchers.

Astrocytes are named for their star shape and are a type of glial cell, which are support cells for neurons in the brain. They play a crucial role in brain functions such as memory, learning, self-repair and synchronization.

“This project stemmed from recent observations in...

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Cause of Alzheimer’s Progression in the Brain

For the first time, researchers have used human data to quantify the speed of different processes that lead to Alzheimer’s disease and found that it develops in a very different way than previously thought. Their results could have important implications for the development of potential treatments.

The international team, led by the University of Cambridge, found that instead of starting from a single point in the brain and initiating a chain reaction which leads to the death of brain cells, Alzheimer’s disease reaches different regions of the brain early. How quickly the disease kills cells in these regions, through the production of toxic protein clusters, limits how quickly the disease progresses overall.

The researchers used post-mortem brain samples from Alzheimer’s pat...

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Sweet! How Glycogen is linked to Heat Generation in Fat Cells

Artistic rendering of a brown fat cell with nucleus in pink, mitochondria in purple and yellow lipid droplets scattered throughout. Image courtesy of Scientific Animations.

Researchers describe how energy expenditure and heat production are regulated in obesity through a previously unknown cellular pathway. Humans carry around with them, often abundantly so, at least two kinds of fat tissue: white and brown. White fat cells are essentially inert containers for energy stored in the form of a single large, oily droplet. Brown fat cells are more complex, containing multiple, smaller droplets intermixed with dark-colored mitochondria — cellular organelles that give them their color and are the “engines” that convert the lipid droplets into heat and energy.

Some people also have “beige”...

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Specific Molecular Mechanism that controls the Transition from Acute to Chronic Pain

Daniele Piomelli
UCI School of Medicine
“This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain,” said Daniele Piomelli, PhD, Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology.

Previously unrecognized control point identified as target for drugs that block transition. A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.

Findings from the study, titled “NAAA-regulated lipid signaling gov...

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