Category Health/Medical

Microneedles Pierce biofilm for more effective Topical Delivery of Antibiotics to Infected Wounds

Rahim Rahimi’s flexible biodegradable microneedle array contains calcium peroxide. The microneedles pierce the biofilm layer of a wound and deliver the medicine to oxygenate the tissue and effectively eradicate biofilm infections on the wound. (Purdue University photo/Vincent Walter)

A Purdue University engineer’s patent-pending invention could improve the quality of life for millions of people suffering from diabetic foot ulcers.

Rahim Rahimi, an assistant professor in the School of Materials Engineering, has developed a flexible polymer composite microneedle array that can overcome the physicochemical bacterial biofilm present in chronic, nonhealing wounds and deliver both oxygen and bactericidal agents simultaneously...

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Elevated Stress Hormones linked to Higher Risk of High Blood Pressure and Heart Events

In a study of more than 400 adults with normal blood pressure, those who had high levels of stress hormones detected in their urine were more likely to develop high blood pressure over the next 6-7 years. Higher levels of the stress hormone cortisol were also linked to an increased risk of cardiovascular events, including heart attack and stroke.

Adults with normal blood pressure and high levels of stress hormones were more likely to develop high blood pressure and experience cardiovascular events compared to those who had lower stress hormone levels, according to new research published today in Hypertension, an American Heart Association journal.

Studies have shown that cumulative exposure to daily stressors and exposure to traumatic stress can increase cardiovascular disease r...

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Cholesterol drives Alzheimer’s Plaque Formation

Amyloid plaques form among neurons in Alzheimer’s disease. New research suggests cholesterol plays a key role.

Cholesterol manufactured in the brain appears to play a key role in the development of Alzheimer’s disease, new research indicates.

Scientists from the University of Virginia School of Medicine and their collaborators found that cholesterol produced by astrocytes is required for controlling the production of amyloid beta, a sticky protein that builds up in the brains of patients with Alzheimer’s. The protein accumulates into insoluble plaques that are a hallmark of the disease. Many efforts have targeted these plaques in the hope that removing or preventing them could treat or prevent Alzheimer’s.

The new findings offer important insights into how and why the plaques for...

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Memory Killer T cells are primed in the Spleen during Influenza infection

Illustration of a T lymphocyte, or T cell, white blood cells targeting SARS-CoV-2 coronavirus particles. T lymphocytes are components of the body's immune system. Helper T cells stimulate other immune cells to act against a pathogen, whereas killer T cells target and destroy infected cells themselves. SARS-CoV-2 emerged in Wuhan, China, in December 2019, and causes a mild respiratory illness (covid-19) that can develop into pneumonia and be fatal in some cases.
This finding upends the long-held paradigm that priming during lung infections takes place only in the draining lymph nodes, and it will be key to developing more efficient vaccinations and therapies for respiratory challenges.

CD8+ T cells – known as “killer” T cells – are the assassins of the immune system. Once they are primed, they seek out and destroy other cells that are infected with virus or cells that are cancerous.

Priming involves dendritic cells – sentinels of the immune system. In an influenza infection in the lungs, for example, lung-migratory dendritic cells capture a piece of the viral antigen, and then migrate out of the lung to the place where naïve T cells reside, to present that antigen to the CD8+ T cells. This primes the T cells to know which cells to attack.

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