Category Health/Medical

Some patients could use special eyedrops instead of reading glasses as they age, researcher says

older men
Credit: CC0 Public Domain

Everybody develops presbyopia as they age—a difficulty in focusing on near objects and text—and often must resort to reading glasses. However, the solution might be as simple as using special eye drops two or three times a day.

A retrospective study of 766 patients presented at the 43rd Congress of the European Society of Cataract and Refractive Surgeons (ESCRS) has found that the majority could read an extra two, three or more lines on the eye chart used for testing near visual acuity (the Jaeger chart) after using specially formulated eye drops. This improvement was sustained for up to two years.

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A ‘universal’ therapy against the seasonal flu? Antibody cocktail targets virus weak spot

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Artist’s representation of non-neutralizing antibodies targeting the flu virus.

An unusual therapy developed at The Jackson Laboratory (JAX) could change the way the world fights influenza, one of the deadliest infectious diseases. In a new study in Science Advances, researchers report that a cocktail of antibodies protected mice—including those with weakened immune systems—from nearly every strain of influenza tested, including avian and swine variants that pose pandemic threats.

Unlike current FDA-approved flu treatments, which target viral enzymes and can quickly become useless as the virus mutates, this therapy did not allow viral escape, even after a month of repeated exposure in animals...

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GIST Research reveals a promising new target to thwart Alzheimer’s decades before symptoms start

A person will have Alzheimer’s years before ever knowing it. The disorienting erasure of memories, language, thoughts—in essence, all that makes up one’s unique sense of self—is the final act of this enigmatic disease that spends decades disrupting vital processes and dismantling the brain’s delicate structure.

Once symptoms surface and doctors make a diagnosis, though, it can often be too late. Damage is widespread, impossible to reverse. No cure exists.

Attempts to develop drugs that clear away toxic accumulations of amyloid-beta and tau proteins—hallmarks of the disease that cause neurons to die—have ended in hundreds of failed clinical trials. Today, some scientists are skeptical over whether removing amyloid plaques is even enough...

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Rapamycin linked to DNA damage resilience in aging human immune cells

DNA
DNA, which has a double-helix structure, can have many genetic mutations and variations. Credit: NIH

University of Oxford-led research finds low-dose rapamycin functions as a genomic protector in aging human immune cells, lowering DNA damage.

The mechanistic target of rapamycin (mTOR) is a central signaling pathway that regulates and coordinates cell growth, metabolism, and survival in response to environmental cues. It helps cells integrate signals from growth factors, nutrients, and stress to control whether they are in an anabolic (building up) or catabolic (breaking down) state.

Aging immune systems accumulate DNA damage linked to immunosenescence. Rapamycin is a drug that inhibits the mTOR pathway...

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