Category Health/Medical

Safeguarding Clean Water for Spaceflight Missions

Biofilms are dense, multispecies aggregates of cells, which clump together in a residue that forms on surfaces. Biofilms are resistant to antimicrobials and notoriously difficult to clean up. They can cause a range of health issues and have a corrosive effect on many materials, including stainless steel, making them a threat to the water supply system of the International Space Station.

In a first study of its kind, scientists characterized different bacterial populations isolated over time from potable (drinking) water from the International Space Station (ISS).

By all appearances, the universe beyond Earth is a vast, lonely, and sterile space. Yet, wherever humans may travel, an abundance of microbial life will follow.

In a first study of its kind, lead author Jiseon Yang at th...

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Study illuminates origins of Lung Cancer in Never Smokers

Genomic and evolutionary classification of lung cancer in never smokers |  Nature Genetics
Landscape of mutational processes in Sherlock-Lung.

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body. This study was conducted by an international team led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and describes for the first time three molecular subtypes of lung cancer in people who have never smoked.

These insights will help unlock the mystery of how lung cancer arises in people who have no history of smoking and may guide the development of more precise clinical treatments. The findings were published September 6, 2021, in Nature Genetics.

“What we’re seeing is that there a...

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Targeting the Gut to Relieve Rheumatoid Arthritis

Targeting the gut to relieve rheumatoid arthritis
Section of graphical abstract from paper. Credit: Med

UCL researchers have shown that damage to the lining of the gut plays an important role in the development of rheumatoid arthritis, paving the way for a new approach to treating the disease.

In the pre-clinical study, which used mouse models and patient samples, the research team propose that restoration of the gut-barrier could offer a new therapeutic approach to reducing the severity of Rheumatoid arthritis (RA) symptoms.

Rheumatoid arthritis is a chronic disease that causes joint pain, swelling, and inflammation...

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Drug cocktail reduces aging-associated disc degeneration

Therapies that target aging cells early pave the way to easing back pain. Chronic back pain affects upwards of 15 million adults in the US, racking up billions in healthcare costs and lost work days. Degeneration of the discs that cushion and support vertebrae, a common occurrence of aging, is a major contributor to low back pain. Although a widespread condition, few treatments are available. Now Jefferson’s Makarand Risbud, PhD, James J. Maguire Jr. Professor of Spine Research in orthopedic surgery, division director of orthopedic research and co-director of the cell biology and regenerative medicine graduate program, and colleagues have shown that treating mice with a drug cocktail that removes aging cells reduces disc degeneration...

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