Taking advantage of knowledge on translation, Hiroshima University researchers examined whether the translational regulatory protein 5MP can suppress RAN translation, which would also suppress the production of the toxic repeat peptide products.
An international research team may have found that a protein implicated in tumor growth may be able to help regulate awry cellular translation and protect against neuronal decay.
Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease...
The gut microbiota comprises trillions of bacteria and other microbes that live in the intestines and affect health in multiple ways. Alpha Tauri 3D Graphics/Shutterstock
Recent research has found that changes in the gut microbiota — the trillions of bacteria and other microbes that live in the intestines — can alter the brain and behavior. Now, a study led by scientists at UCLA could elucidate how and why that phenomenon occurs.
In the experiment, which was conducted with mice, researchers found that gut microbes can exacerbate the effects of cognitive impairment because of how they affect the hippocampus, the region of the brain that is critical for memory and learning...
Mariana Byndloss, DVM, PhD, Woongjae Yoo, PhD, and colleagues are studying how a high-fat diet contributes to heart disease. (photo by Donn Jones, taken prior to revised masking guidelines)
A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.
The discoveries in animal models support a key role for the intestines and microbiota in the development of cardiovascular disease, said Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center.
The intestines, she noted, have been relatively understudied by scientists seeking to unders...
Mitochondria (labeled with anti-COXIV antibody) can be detected in lupus red blood cells (labeled with Band-3 antibody) but not in healthy red blood cells.
The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a study led by researchers at Weill Cornell Medicine. The discovery could lead to new methods for classifying and treating patients with this disease.
The researchers, who published their findings August 11 in Cell, found that in a number of lupus patients, maturing red blood cells fail to get rid of their mitochondria — tiny molecular reactors that help convert oxygen into chemical energy in most cell types, but are normally excluded from red blood cells...
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