Category Health/Medical

Laughing Gas Relieves Symptoms in people with Treatment-Resistant Depression

Researchers at Washington University School of Medicine in St. Louis and the University of Chicago have found that a single, one-hour treatment that involves breathing in a mixture of oxygen and the anesthetic drug nitrous oxide — otherwise known as laughing gas — can significantly improve symptoms in people with treatment-resistant depression.

Single treatment provides patients with rapid, lasting antidepressant effects. A single, one-hour treatment that involves breathing in a mixture of oxygen and nitrous oxide — otherwise known as laughing gas — significantly improved symptoms in people with treatment-resistant depression, according to new data from researchers at Washington University School of Medicine in St. Louis and the University of Chicago.

In a phase 2 clinical trial...

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Microgel Coating gives Donor Cells a Boost in Reversing Pulmonary Fibrosis

Gel-coated (red) mesenchymal stromal cells (yellow) can degrade collagen (green) over a distance in the presence of tumor necrosis factor-alpha. (Image: Jae-Won Shin and Sing-Wan Wong/UIC)

Single cell encapsulation in gel can optimize cell-based therapy. Researchers at the University of Illinois Chicago have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair through treatment with microgel-coated mesenchymal stromal cells.

Pulmonary fibrosis is a chronic disease caused by environmental toxins, medications or medical conditions like pneumonia and rheumatoid arthritis...

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New study further Advances the Treatment of Chronic Pain

New study further advances the treatment of chronic pain
Pinwheel flower. Credit: LIH

Scientists have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/ CXCR7 that regulates opioid peptides naturally produced in the brain. The researchers also developed a synthetic analogue of conolidine, RTI-5152-12, which displays an even greater activity on the receptor.

These findings, which were published on June 3rd in the international journal Signal Transduction and Targeted Therapy (Nature publishing group), further advance the understanding of pain regulation and open alternative therapeutic avenues for the treatment of chronic pain.

Opioid peptides are small proteins that mediate pain relief and emotions, in...

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The Powerhouse Future is Flexoelectric

pacemaker
Pacemakers implanted in human hearts and utilizing lithium batteries could instead be self-powered as natural movement generates electrical power.

‘Giant flexoelectricity’ breakthrough in soft elastomers paves way for improved robots and self-powered pacemakers. Researchers have demonstrated “giant flexoelectricity” in soft elastomers that could improve robot movement range and make self-powered pacemakers a real possibility. In a paper published this month in the Proceedings of the National Academy of Sciences, scientists from the University of Houston and Air Force Research Laboratory explain how to engineer ostensibly ordinary substances like silicone rubber into an electric powerhouse.

What do the following have in common: a self-powered implanted medical device, a soft human-li...

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