Category Health/Medical

Latest advance in targeted delivery of therapeutic proteins. A team of researchers at the Center for Bioactive Delivery at the University of Massachusetts Amherst’s Institute for Applied Life Sciences has engineered a nanoparticle that has the potential to revolutionize disease treatment, including for cancer. This new research, which appears today in Angewandte Chemie, combines two different approaches to more precisely and effectively deliver treatment to the specific cells affected by cancer.

Two of the most promising new treatments involve delivery of cancer-fighting drugs via biologics or antibody-drug conjugates (ADCs). Each has its own advantages and limitations...

Alzheimer’s disease is caused by protein deposits in the brain and the rapid loss of brain matter. But a Mediterranean diet rich in fish, vegetables and olive oil might protect the brain from these disease triggers. In Alzheimer’s disease, neurons in the brain die. Largely responsible for the death of neurons are certain protein deposits in the brains of affected individuals: So-called beta-amyloid proteins, which form clumps (plaques) between neurons, and tau proteins, which stick together the inside of neurons. The causes of these deposits are as yet unclear. In addition, a rapidly progressive atrophy, i.e. a shrinking of the brain volume, can be observed in affected persons...

Researchers at the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL) developed a breakthrough in energy-efficient phototransistors. Such devices could eventually help computers process visual information more like the human brain and be used as sensors in things like self-driving vehicles.

The structures rely on a new type of semiconductor — metal-halide perovskites — which have proven to be highly efficient at converting sunlight into electrical energy and shown tremendous promise in a range of other technologies.

“In general, these perovskite semiconductors are a really unique functional system with potential benefits for a number of different technologies,” said Jeffrey Blackb...

University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.

This enzyme, NEDD4-2, is critical for kidney health, says UniSA Centre for Cancer Biology scientist Dr Jantina Manning in a new paper published this month in Cell Death & Disease.

The early career researcher and her colleagues, including 2020 SA Scientist of the Year Professor Sharad Kumar, have shown in an animal study the correlation between a high salt diet, low levels of NEDD4-2 and advanced kidney disease.

While a high salt diet can exacerbate some forms of kidney disease, until now, researchers did not realise that NEDD4-2 plays a role in promoting this salt-induced k...