Category Health/Medical

Neural Plasticity depends on this long Noncoding RNA’s Journey from Nucleus to Synapse

When the brain’s synapses are activated, they set off a signaling cascade that results in the expression of long noncoding RNA called “ADEPTR.” The RNA is quickly transported along dendrites to synapses, where it acts on proteins involved in remodeling. (Image courtesy of Jenna Wingfield and Yibo Zhao of the Puthanveettil lab at Scripps Research)

Making memories involves more than seeing friends or taking photos. The brain constantly adapts to new information and stores memories by building connections among neurons, called synapses. How neurons do this — reaching out arm-like dendrites to communicate with other neurons — requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery.

A new study from scientists at Scripps Research and the Max P...

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Self-assembling Nanofibers Prevent Damage from Inflammation

The graphic shows the peptide nanofiber bearing complement protein C3dg (blue) and key components of the TNF protein, which include B-cell epitopes (green), and T-cell epitopes (purple). Credit: Chelsea Fries
The graphic shows the peptide nanofiber bearing complement protein C3dg (blue) and key components of the TNF protein, which include B-cell epitopes (green), and T-cell epitopes (purple). Credit: Chelsea Fries

Nanomaterials strategically activate the immune system to fight inflammation as effectively as current standard therapeutics

Biomedical engineers at Duke University have developed a self-assembling nanomaterial that can help limit damage caused by inflammatory diseases by activating key cells in the immune system. In mouse models of psoriasis, the nanofiber-based drug has been shown to mitigate damaging inflammation as effectively as a gold-standard therapy.

One of the hallmarks of inflammatory diseases, like rheumatoid arthritis, Crohn’s disease and psoriasis, is the overpr...

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Dietary Cocoa improves Health of Obese Mice; likely has Implications for Humans

This study used a commercially available cocoa product at a “physiologically achievable dose” — meaning its equivalent could be duplicated by humans. For people it works out to about 10 tablespoons of cocoa powder a day.
 IMAGE: GETTYIMAGES FCAFOTODIGITAL

Supplementation of cocoa powder in the diet of high-fat-fed mice with liver disease markedly reduced the severity of their condition, according to a new study by Penn State researchers, who suggest the results have implications for people.

Cocoa powder, a popular food ingredient most commonly used in the production of chocolate, is rich in fiber, iron and phytochemicals reported to have positive health benefits, including antioxidant polyphenols and methylxanthines, noted study leader Joshua Lambert, professor of food science ...

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Toxic Gas in Rat Brains shows potential for new Dementia Treatments

Scans of a brain from an fMRI

A potential treatment for dementia and epilepsy could look to reduce the amounts of a toxic gas in the brain has been revealed in a new study using rat brain cells.

The research published in Scientific Reports shows that treatments to reduce levels of hydrogen sulfide (H2S) in the brain may help to ward off damage caused by the gas. By testing rat brain cells, the team of scientists from the University of Reading, University of Leeds and John Hopkins University in the USA found that H2S is involved in blocking a key brain cell gateway that helps the brain to communicate effectively.

Dr Mark Dallas, Associate Professor in Cellular Neuroscience at the University of Reading said:

“This is an exciting finding as it gives us new insights about the role of hydrogen sulfide in vario...

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