Category Health/Medical

Regenerating Hair Follicle Stem Cells

Mouse hair follicle.
Underneath the mouse hair follicle, dermal papilla cells (green) produce the Gas6 molecule that activates hair follicle stem cells. Credit: Hsu Laboratory, Harvard University

Harvard University researchers have identified the biological mechanism of how chronic stress impairs hair follicle stem cells, confirming long-standing observations that stress might lead to hair loss.

In a mouse study published in the journal Nature, the researchers found that a major stress hormone causes hair follicle stem cells to stay in an extended resting phase, without regenerating the hair follicle and hair...

Read More

Selenium Supplementation Protects against Obesity and may Extend Lifespan

mice

Adding the nutrient selenium to diets protects against obesity and provides metabolic benefits to mice, according to a study published today in eLife.

The results could lead to interventions that reproduce many of the anti-aging effects associated with dietary restriction while also 1allowing people to eat as normal.

Several types of diet have been shown to increase healthspan—that is, the period of healthy lifespan. One of the proven methods of increasing healthspan in many organisms, including non-human mammals, is to restrict dietary intake of an amino acid called methionine.

Recent studies have suggested that the effects of methionine restriction on healthspan are likely to be conserved in humans...

Read More

Protein Rewires Metabolism to Block Cancer Cell Death, may allow cancer Spread

Zachary Schafer working in the lab.
Zachary Schafer working in the lab.

One specific protein may be a master regulator for changing how cancer cells consume nutrients from their environments, preventing cell death and increasing the likelihood the cancer could spread, a study from the University of Notre Dame has shown.

The study, published in Cell Reports, was completed in the laboratory of Zachary Schafer, the Coleman Foundation Associate Professor of Cancer Biology in the Department of Biological Sciences.

Schafer and collaborators found a protein called SGK1, known to be activated in a variety of cancer cell types, signals the cell to take up nutrients...

Read More

Scientists use Nanotechnology to Detect Bone-Healing Stem Cells

Microscopic image of enriched skeletal stem cells using gold nanoparticles.

Researchers at the University of Southampton have developed a new way of using nanomaterials to identify and enrich skeletal stem cells — a discovery which could eventually lead to new treatments for major bone fractures and the repair of lost or damaged bone.

Working together, a team of physicists, chemists and tissue engineering experts used specially designed gold nanoparticles to ‘seek out’ specific human bone stem cells — creating a fluorescent glow to reveal their presence among other types of cells and allow them to be isolated or ‘enriched’.

The researchers concluded their new technique is simpler and quicker than other methods and up to 50-500 times more effective at enriching stem cells.

The ...

Read More