Category Health/Medical

Drug is promising against Pancreatic and Breast Cancers

Modulation of Cancer-Associated Fibrotic Stroma by An Integrin αvβ3 Targeting Protein for Pancreatic Cancer Treatment

ProAgio, a drug developed by Georgia State University biology professor Zhi-Ren Liu and his team, is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology.

A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis.

ProAgio, created from a human protein, targets the cell surface receptor  integrin αvβ3 which is expressed on cancer-associated fibroblasts...

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Coffee lovers, rejoice! Drinking more coffee associated with Decreased Heart Failure Risk

Image result for Coffee lovers, rejoice! Drinking more coffee associated with Decreased Heart Failure Risk

Circulation: Heart Failure Journal Report..Dietary information from 3 large, well-known heart disease studies suggests drinking one or more cups of caffeinated coffee may reduce heart failure risk, according to research published today in Circulation: Heart Failure, an American Heart Association journal.

Coronary artery disease, heart failure and stroke are among the top causes of death from heart disease in the U.S. “While smoking, age and high blood pressure are among the most well-known heart disease risk factors, unidentified risk factors for heart disease remain,” according to David P. Kao, M.D...

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Study links exposure to Nighttime Artificial Lights with Elevated Thyroid Cancer Risk

Credit: marekr from Pixabay

Study links exposure to nighttime artificial lights with elevated thyroid cancer risk. People living in regions with high levels of outdoor artificial light at night may face a higher risk of developing thyroid cancer. The finding comes from a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Over the past century, nightscapes — especially in cities — have drastically changed due to the rapid growth of electric lighting. Also, epidemiological studies have reported an association between higher satellite-measured levels of nighttime light and elevated breast cancer risk...

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Fungi in the Gut prime Immunity against Infection

Graphic depicting relationship between fungi in gut, antibody levels and CARD gene
Relationship between gut fungi, anti-fungal antibodies, CARD9 gene, and fungal immunity. Image courtesy of the Iliev lab.

Common fungi, often present in the gut, teach the immune system how to respond to their more dangerous relatives, according to new research from scientists at Weill Cornell Medicine. Breakdowns in this process can leave people susceptible to deadly fungal infections.

The study, published Feb. 5 in Cell, reveals a new twist in the complex relationship between humans and their associated microbes, and points the way toward novel therapies that could help combat a rising tide of drug-resistant pathogens.

The new discovery stemmed from work on inflammatory bowel disease, which often causes patients to carry larger than normal populations of fungi in their guts...

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