Category Health/Medical

Blocking gene expression in mitochondria in mice stops cancer cells from growing. A newly developed compound starves cancer cells by attacking their “power plants” — the mitochondria. The new compound prevents the genetic information within mitochondria from being read. Researchers from the Max Planck Institute for Biology of Ageing in Cologne, the Karolinska Institute in Stockholm and the University of Gothenburg report in their study that this compound could be used as a potential anti-tumour drug in the future; not only in mice but also in human patients.

Mitochondria provide our cells with energy and cellular building blocks necessary for normal tissue and organ function...

Scientists describe how a phenomenon known as ‘chromothripsis’ breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.

In a paper published in the December 23, 2020 online issue of Nature, researchers at University of California San Diego School of Medicine and the UC San Diego branch of the Ludwig Institute for Cancer Research, with colleagues in New York and the United Kingdom, describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that ultimately promote cancer ce...

Dual-acting immuno-antibiotics block an essential pathway in bacteria and activate the adaptive immune response. Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today in Nature.

The World Health Organization (WHO) has declared AMR as one of the top 10 global public health threats against humanity. It is estimated that by 2050, antibiotic-resistant infections could claim 10 million lives each year and impose a cumulative $100 trillion burden on the global economy...

In cell culture, loperamide, a drug commonly used against diarrhea, proves effective against glioblastoma cells. A research team has now unraveled the drug’s mechanisms of action of cell death induction and – in doing so – has shown how this compound could help attack brain 7mtumors that otherwise are difficult to treat.

The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe Unive...