Category Health/Medical

‘Relaxed’ T Cells Critical to Immune Response

Rice University scientists’ simple model of T cell activation of the immune response shows the T cell binding, via a receptor (TCR) to an antigen-presenting cell (APC). If an invader is identified as such, the response is activated, but only if the “relaxation” time of the binding is long enough. Illustration by Hamid Teimouri

Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: Quickly finding a few invaders among the many imposters in your body to trigger its immune response.

T cells have to react fast and do so nearly perfectly to protect people from diseases. But first, they need a little “me” time.

Rice University researchers suggest that has to do with how T cells “relax” in the process of binding to ligands—shor...

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Diluting Blood Plasma Rejuvenates Tissue, Reverses Aging in Mice

Older mice grew significantly more new muscle fibers, shown as pink “donut” shapes, after undergoing a procedure that effectively diluted the proteins in their blood plasma (bottom) than they did before they underwent the procedure (top). Credit: Irina Conboy

In 2005, University of California, Berkeley, researchers made the surprising discovery that making conjoined twins out of young and old mice—such that they share blood and organs—can rejuvenate tissues and reverse the signs of aging in the old mice. The finding sparked a flurry of research into whether a youngster’s blood might contain special proteins or molecules that could serve as a “fountain of youth” for mice and humans alike.

But a new study by the same team shows that similar age-reversing effects can be achieve...

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Super-potent Human Antibodies protect against COVID-19 in Animal Tests

A human antibody (blue) attaches to the receptor binding domain (red) on the SARS-CoV-2 virus. (Model courtesy of the Burton lab.)

Scientists isolate powerful coronavirus-neutralizing antibodies from COVID-19 patients and successfully test in animals. A team led by Scripps Research has discovered antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2, the coronavirus that causes the disease, when tested in animals and human cell cultures.

The research, published today in Science, offers a paradigm of swift reaction to an emergent and deadly viral pandemic, and sets the stage for clinical trials and additional tests of the antibodies, which are now being produced as potential treatments and preventives for COVID-19.

“The discover...

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Artificial Synapse that works with Living Cells created

A 2017 photo of Alberto Salleo, associate professor of materials science and engineering, and graduate student Scott Keene characterizing the electrochemical properties of a previous artificial synapse design. Their latest artificial synapse is a biohybrid device that integrates with living cells. (Image credit: L.A. Cicero)

Researchers have created a device that can integrate and interact with neuron-like cells. This could be an early step to an artificial synapse for use in brain-computer interfaces. In 2017, Stanford University researchers presented a new device that mimics the brain’s efficient and low-energy neural learning process...

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