Category Health/Medical

Receptor makes Mice Strong and Slim

Mouse on exercise wheel | Credit: © Emilia Stasiak / stock.adobe.com

Molecule that regulates two side effects of aging identified. Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn have discovered a receptor in mice that regulates both effects. Experiments with human cell cultures suggest that the corresponding signaling pathways might also exist in humans. The study, which also involved researchers from Spain, Finland, Belgium, Denmark and the USA, has now been published in the journal Cell Metabolism.

The surfaces of some cells are virtually teeming with A2B receptors, for example in the so-called brown adipose tissue. Brown adipose tissue, unlike its white-colored counterpart, is not used to store fat. Instead, it burns fat and thereby generates heat.

“In our publication we to...

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Researchers Print, Tune Graphene Sensors to Monitor Food Freshness, Safety

Researchers are using aerosol-jet-printing technology to create these graphene biosensors that can detect histamine, an allergen and indicator of spoiled fish and meat. Image courtesy of Jonathan Claussen.

Researchers are using high-resolution printing technology and the unique properties of graphene to make low-cost biosensors to monitor food safety and livestock health.

It turned out the sensors — printed with high-resolution aerosol jet printers on a flexible polymer film and tuned to test for histamine, an allergen and indicator of spoiled fish and meat — can detect histamine down to 3.41 parts per million.

The U.S...

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One-time Treatment Generates New Neurons, Eliminates Parkinson’s disease in mice

Left: mouse astrocytes (green) before reprogramming; Right: neurons (red) induced from mouse astrocytes after reprogramming with PTB antisense oligonucleotide treatment.

Researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.

Xiang-Dong Fu, PhD, has never been more excited about something in his entire career. He has long studied the basic biology of RNA, a genetic cousin of DNA, and the proteins that bind it. But a single discovery has launched Fu into a completely new field: neuroscience.

For decades, Fu and his team at University of California San Diego School of Medicine studied a pr...

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Protein in Mitochondria appears to Regulate Halth and Longevity

Having greater amounts of the peptide humanin is closely correlated with longer lives and better health in both animals and humans, including lower risk for Alzheimer’s.

A new study led by researchers at the USC Leonard Davis School of Gerontology is the first to demonstrate that a tiny protein has a big impact on health and longevity in both animals and humans.

The researchers examined humanin, a peptide encoded in the small genome of mitochondria — the powerhouses of the cell. From experiments in laboratory animals to measurements in human patients, the multi-site collaboration demonstrates how higher levels of humanin in the body are connected to longer lifespans and better health. It is linked to a lower risk for diseases such as Alzheimer’s.

“Humanin has long been known to...

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