Category Health/Medical

Super-potent Human Antibodies protect against COVID-19 in Animal Tests

A human antibody (blue) attaches to the receptor binding domain (red) on the SARS-CoV-2 virus. (Model courtesy of the Burton lab.)

Scientists isolate powerful coronavirus-neutralizing antibodies from COVID-19 patients and successfully test in animals. A team led by Scripps Research has discovered antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2, the coronavirus that causes the disease, when tested in animals and human cell cultures.

The research, published today in Science, offers a paradigm of swift reaction to an emergent and deadly viral pandemic, and sets the stage for clinical trials and additional tests of the antibodies, which are now being produced as potential treatments and preventives for COVID-19.

“The discover...

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Artificial Synapse that works with Living Cells created

A 2017 photo of Alberto Salleo, associate professor of materials science and engineering, and graduate student Scott Keene characterizing the electrochemical properties of a previous artificial synapse design. Their latest artificial synapse is a biohybrid device that integrates with living cells. (Image credit: L.A. Cicero)

Researchers have created a device that can integrate and interact with neuron-like cells. This could be an early step to an artificial synapse for use in brain-computer interfaces. In 2017, Stanford University researchers presented a new device that mimics the brain’s efficient and low-energy neural learning process...

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Newly Synthesized Fungal Compound can switch on a Self-Destruct Button for Cancer

A newly synthesized version of a fungal compound could be a powerful new tool against cancer
A newly synthesized version of a fungal compound could be a powerful new tool against cancer
vitanovski/Depositphotos

Leading organic chemists synthesize fungal molecule capable of reactivating the self-destruct gene in aggressive cancer cells. Cancers cells use a special technique to propagate; they delete their ‘programmed death’ gene through mutation, ‘forget’ to die when their lifetime is over, and continue to grow instead. A research team has developed a method through which a fungal compound capable of rearming the self-destruct gene in certain cancer cells can be artificially produced in marketable quantities, providing a potential cancer therapeutic strategy.

All human body cells have a certain lifespan, during which they perform their essential duties...

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A good Vitamin D status can Protect against Cancer

Fig. 1
Vitamin D signaling. Production of vitamin D3 and its metabolites 25(OH)D3 and 1,25(OH)2D3 (A). VDR (green) binds accessible genomic DNA in complex with a partner protein (RXR or others, blue) (B). VDR’s DNA binding is supported by the pioneer factors PU.1, CEBPA and/or GABPA. The genomic region that can be influenced by 1,25(OH)2D3 (via binding to VDR) is restricted by CTCF proteins defining left and right TAD borders. Schematic representation of a Voronoi tessellation [55] displaying five TAD classes of the most prominently enriched biological processes (C). The most relevant attributes are the number of persistent and transient VDR sites and were chosen for the x and y axis, respectively.

A good vitamin D status is beneficial both in cancer prevention and in the prognosis of sever...

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