Category Health/Medical

Molecular ‘Switch’ Reverses Chronic Inflammation and Aging

A molecular modeling image showing the detector portion of the NLRP3 inflammasome in red, magenta, and yellow
The NLRP3 receptor protein is responsible for detecting potential pathogens in the body and launching an immune response. (Image by MLGProGamer123 via Wikimedia Commons)

Chronic inflammation, which results when old age, stress or environmental toxins keep the body’s immune system in overdrive, can contribute to a variety of devastating diseases, from Alzheimer’s and Parkinson’s to diabetes and cancer.

Now, scientists at the University of California, Berkeley, have identified a molecular “switch” that controls the immune machinery responsible for chronic inflammation in the body. The finding, which appears online Feb. 6 in the journal Cell Metabolism, could lead to new ways to halt or even reverse many of these age-related conditions.

“My lab is very interested in unde...

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Portable Lab you Plug into your Phone can Diagnose Illnesses like Coronavirus

UC engineers developed a smartphone app that can record and transmit test results from a portable lab that people can plug into their phones. The lab uses saliva from plastic test strips that people put in their mouths like a sucker. Photo/Joseph Fuqua II/UC Creative Services

Engineers with the University of Cincinnati have created a tiny portable lab that plugs into your phone, connecting it automatically to a doctor’s office through a custom app UC developed. The lab the size of a credit card can diagnose infectious diseases such as coronavirus, malaria, HIV or Lyme disease or countless other health conditions like depression and anxiety.

The patient simply puts a single-use plastic lab chip into his or her mouth then plugs that into a slot in the box to test the saliva.

The ...

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A New Substance Prevents Vascular Calcification

heating elements covered in limescale
Just as heating elements become covered in limescale, some diseases cause calcification in the soft tissues of the body. (Photograph: Shutterstock)

Researchers at ETH Zurich and ETH spin-off Inositec have developed a new substance to prevent vascular calcification, which affects many patients suffering from chronic kidney disease. As their metabolism is impaired, calcium salts may deposit in soft tissues, such as blood vessels or even the heart valves, causing them to stiffen. This often leads to severe, potentially fatal cardiovascular diseases. However, before patients can benefit from the substance further research and tests must be carried out.

“Calcification occurs when calcium phosphate crystals are deposited in tissue,” explains Jean-Christophe Leroux, Professor of Drug For...

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Coin-sized Smart Insulin Patch, Potential Diabetes Treatment

New device to automatically manage glucose levels and deliver needed insulin quickly

UCLA bioengineers and colleagues at UNC School of Medicine and MIT have further developed a smart insulin-delivery patch that could one day monitor and manage glucose levels in people with diabetes and deliver the necessary insulin dosage. The adhesive patch, about the size of a quarter, is simple to manufacture and intended for once-a-day use.

The study, published in Nature Biomedical Engineering, describes research conducted on mice and pigs. The research team, led by Zhen Gu, PhD, professor of bioengineering at the UCLA Samueli School of Engineering, is applying for FDA approval of clinical trials in humans...

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