Category Health/Medical

Researchers build a Particle Accelerator that fits on a Chip, miniaturizing a technology that can now find new applications in research and medicine

This image, magnified 25,000 times, shows a section of an accelerator-on-a-chip. The gray structures focus infrared laser light (shown in yellow and purple) on electrons flowing through the center channel. By packing 1,000 channels onto an inch-sized chip, Stanford researchers hope to accelerate electrons to 94 percent of the speed of light. (Image credit: Courtesy Neil Sapra

On a hillside above Stanford University, the SLAC National Accelerator Laboratory operates a scientific instrument nearly 2 miles long...

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Delivering TB vaccine Intravenously dramatically Improves Potency, study shows

3D PET CT scans of monkey lungs showing inflammation (red and yellow) from TB infection. The top row were vaccinated the usual way with a shot into the skin The bottom row received the vaccine intravenously.
CREDIT
JoAnne Flynn, Ph.D., Alexander White, Pauline Maiello, and Mario Roederer, Ph.D.

Worldwide, more people die from tuberculosis (TB) than any other infectious disease, even though the vast majority were vaccinated. The vaccine just isn’t that reliable. But a new Nature study finds that simply changing the way the vaccine is administered could dramatically boost its protective power.

Researchers at the University of Pittsburgh School of Medicine and the National Institute of Allergy and Infectious Diseases (NIAID) discovered that intravenous TB vaccination is highly protecti...

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Objective Subtle Cognitive Difficulties predict Amyloid Accumulation and Neurodegeneration

A rendering of amyloid protein plaques accumulating between neurons in the brain
A rendering of amyloid protein plaques accumulating between neurons in the brain. Credit: National Institute of Aging

Rresearchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report that accumulating amyloid – an abnormal protein linked to neurodegenerative conditions such as Alzheimer’s disease (AD) – occurred faster among persons deemed to have “objectively-defined subtle cognitive difficulties” (Obj-SCD) than among persons considered to be “cognitively normal.”

Classification of Obj-SCD, which has been previously shown to predict progression to mild cognitive impairment (MCI) and dementia, is determined using non-invasive but sensitive neuropsychological measures, including measures of how efficiently someone learns ...

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Learning from the Bears

Grizzly bears’ muscles manage to survive hibernation virtually unharmed. Researchers are trying to understand the mechanisms behind this ability in order to help bedridden patients.
© Gotthardt Lab, MDC

Grizzly bears spend many months in hibernation, but their muscles do not suffer from the lack of movement. In the journal Scientific Reports, a team led by Michael Gotthardt reports on how they manage to do this. The grizzly bears’ strategy could help prevent muscle atrophy in humans as well.

A grizzly bear only knows three seasons during the year. Its time of activity starts between March and May. Around September the bear begins to eat large quantities of food. And sometime between November and January, it falls into hibernation...

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