Category Health/Medical

Hydrogels Control Inflammation to Help Healing

An illustration shows how effective a selection of custom-designed peptide hydrogels are in controlling inflammation. The gels developed at Rice University serve as scaffolds for new tissue and show promise for treating wounds and cancer and for delivering drugs. The hydrogels are designed to dissolve in the body as they are replaced by natural, functional tissue. Illustration by Tania Lopez-Silva

Scientists model how synthetic gels can tune body’s inflammatory response. Hydrogels for healing, synthesized from the molecules up by Rice University bioengineers, are a few steps closer to the clinic.

Rice researchers and collaborators at Texas Heart Institute (THI) have established a baseline set of injectable hydrogels that promise to help heal wounds, deliver drugs and treat cancer...

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Mitochondria are the ‘Canary in the Coal Mine’ for Cellular Stress

Pictured are mitochondria (red), cell nuclei (blue) and mtDNA (white dots).
Credit: Salk Institute/Waitt Advanced Biophotonics Center

How some cancers resist chemotherapy…
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or chemicals that can damage DNA, such as chemotherapy. The results, published online in Nature Metabolism on December 9, 2019, could lead to new cancer treatments that prevent tumors from becoming resistant to chemotherapy.

“Mitochondria are acting as a first line of defense in sensing DNA stress...

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Herpes’s Achilles Heel

microscopy image of herpes simplex virus
Scientists have used gene editing to disrupt both latent and actively replicating herpes simplex virus in human cells. Image: Aunt_Spray/iStock/Getty Images

In a first, scientists use gene-editing to disrupt both latent and active herpes virus in human cells. Scientists have used the gene-editing tool CRISPR-Cas9 to disrupt both latent reservoirs of the herpes simplex virus and actively replicating virus in human fibroblast cells. Experiments pinpoint weak spot that can make the virus susceptible to gene editing.

The herpes simplex virus, commonly known as the cold sore virus, is a devious microbe.

It enters the body through regions lined with mucous membranes – mouth, nose and genitals – but quickly establishes lifelong viral hideouts inside nerve cells...

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Poor Diet linked to Age-Related Macular Degeneration

Image result for Poor diet linked to age-related macular degeneration
Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study. British Journal of Ophthalmology, 2019; bjophthalmol-2019-314813 DOI: 10.1136/bjophthalmol-2019-314813

Participants who ate a diet high in red and processed meat, fried food, refined grains and high-fat dairy were 3X more likely to develop an eye condition that damages the retina and affects a person’s central vision, according to the results of a study from the University at Buffalo.

The condition is called late-stage age-related macular degeneration (AMD). AMD is an irreversible condition that affects a person’s central vision, taking away their ability to drive, among other common daily activities.

“Treatment for late, neovascular AMD is invasive and expens...

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