Category Health/Medical

Newly identified Bacteria-killing Protein needs Vitamin A to work


Highlights

Skin microbiota induces epidermal RELMα, which kills bacteria via membrane disruption
RELMα-deficient mice have altered skin microbiota and are more susceptible to infection
Dietary vitamin A is required for RELMα expression
RELMα is required for vitamin-A-dependent resistance to skin infection

People who have inadequate vitamin A in their diets are more susceptible to skin infection, yet how that vitamin affects skin immunity has been unclear. In a study published today, UT Southwestern researchers shed some light on that mystery by identifying a previously unknown bacteria-killing protein on the epidermis that requires the vitamin to work.

The researchers found that one protein in the resistin-like molecule (RELM) family – RELMα – acts as an antibiotic to rapidly kill...

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Flu virus’ best friend: Low Humidity


Low humidity increases influenza disease through caspase-1/11 activation. WT Mx1 mice or caspase-1/11 KO Mx1 mice were preconditioned at 10% and 50% RH for 5 d and challenged with aerosolized hvPR8 at 2 × 105pfu/mL for 15 min (n = 6 mice per group). (A and B) Weight loss was monitored for 14 d. Data are representative of four experiments and means ± SEM *P < 0.05; one-way ANOVA; Student’s t test.

Yale researchers have pinpointed a key reason why people are more likely to get sick and even die from flu during winter months: low humidity. While experts know that cold temperatures and low humidity promote transmission of the flu virus, less is understood about the effect of decreased humidity on the immune system’s defenses against flu infection.

The Yale research team, led by Ak...

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Common Food Additive Found to Affect Gut Microbiota


Impact of the food additive titanium dioxide (E171) on gut microbiota-host interactionFrontiers in Nutrition, 2019

Titanium dioxide nanoparticles E171 may impact human health. University of Sydney research provides new evidence that nanoparticles, which are present in many food items, may have a substantial and harmful influence on human health. E171 is commonly used in high quantities in foods and some medicines as a whitening agent. Found in more than 900 food products such as chewing gum and mayonnaise, E171 is consumed in high proportion everyday by the general population.

Published in Frontiers in Nutrition, the mice study found that consumption of food containing E171 has an impact on the gut microbiota (defined by the trillions of bacteria that inhabit the gut) which coul...

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New Brain Tumor Imaging technique uses Protein found in Scorpion Venom

A Deathstalker scorpion sits in a jar illuminated by ultraviolet light in a laboratory. Photo by Getty.

A Deathstalker scorpion sits in a jar illuminated by ultraviolet light in a laboratory. Photo by Getty.

A novel imaging technique that uses a synthesized form of scorpion venom to light up brain tumors has shown promise in a clinical trial. The imaging system enables neurosurgeons to better see malignant growths that often are difficult to fully eliminate. Results from the multi-institutional clinical trial, led by investigators from Cedars-Sinai and sponsored by Blaze Bioscience, Inc., appear in the journal Neurosurgery.

The new imaging technique that was studied uses a special high-sensitivity near-infrared camera developed at Cedars-Sinai, along with the imaging agent tozuleristide, or BLZ-100, developed by Blaze...

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