Category Health/Medical

Researchers Wirelessly Hack ‘Boss’ Gene, a step toward Reprogramming the human Genome

Two microscope images showing the FGFR1 in its normal state and when it's activated by laser light.
The left image above shows the gene FGFR1 in its natural state. The right image shows the gene when exposed to laser light, which causes the gene to activiate and deactivate. Credit: University at Buffalo.

Advance, made possible by tiny photonic implants, could lead to new treatments for cancer, mental disorders. A new University at Buffalo-led study describes how researchers wirelessly controlled FGFR1 – a gene that plays a key role in how humans grow from embryos to adults – in lab-grown brain tissue.

The ability to manipulate the gene, the study’s authors say, could lead to new cancer treatments, and ways to prevent and treat mental disorders such as schizophrenia. The work – spearheaded by UB researchers Josep M. Jornet, Michal K. Stachowiak, Yongho Bae and Ewa K...

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New research identifies gene that Hides Cancer cells from Immunotherapy

Highlights

•The early embryonic transcription factor DUX4 is active in many human cancers
•DUX4-expressing cancers are characterized by low anti-tumor immune activity
•DUX4 blocks interferon-γ-mediated induction of MHC class I and antigen presentation
•DUX4 is significantly associated with failure to respond to anti-CTLA-4 therapy

A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. The study, published today in Developmental Cell, found that when the DUX4 gene is expressed in cancer cells, it can prevent the cancer from being recognized and destroyed by the immune system.

The team, led by Drs...

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New Cell discovered that can Heal Hearts

These are photos of the hearts from two mice, one month after a heart event.
These are photos of the hearts from two mice, one month after a heart event.

Fundamental scientific discovery could lead to new ways to repair damaged hearts. University of Calgary researchers are the first to discover a previously unidentified cell population in the pericardial fluid found inside the sac around the heart. The discovery could lead to new treatments for patients with injured hearts. The study led by Drs. Paul Kubes, PhD, Justin Deniset, PhD and Paul Fedak, MD, PhD is published in the journal Immunity.

The Kubes lab, in collaboration with the Fedak lab, found that a specific cell, a Gata6+ pericardial cavity macrophage, helps heal an injured heart in mice. The cell was discovered in the pericardial fluid (sac around the heart) of a mouse with heart injury...

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Vast majority of Dietary Supplements Don’t Improve Heart health or put off Death, study finds

7-16-19 Save Your Money: Vast Majority Of Dietary Supplements Don’t Improve Heart Health or Put .jpg
Credit: Johns Hopkins Medicine

In a massive new analysis of findings from 277 clinical trials using 24 different interventions, Johns Hopkins Medicine researchers say they have found that almost all vitamin, mineral and other nutrient supplements or diets cannot be linked to longer life or protection from heart disease.

Although they found that most of the supplements or diets were not associated with any harm, the analysis showed possible health benefits only from a low-salt diet, omega-3 fatty acid supplements and possibly folic acid supplements for some people. Researchers also found that supplements combining calcium and vitaminD may in fact be linked to a slightly increased stroke risk. Results of the analysis were published on July 8 in Annals of Internal Medicine.

Survey...

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