Category Health/Medical

Circadian Clocks: Body parts respond to day and night Independently from Brain, studies show

UCI research helps shed new light on circadian clocks
The future implications of our findings are vast,” says Paolo Sassone-Corsi, senior author of one of the two studies on circadian clocks published today in the journal Cell. He directs UCI’s Center for Epigenetics and Metabolism and is a Donald Bren Professor of Biological Chemistry. Penny Lee / UCI School of Medicine

Can your liver sense when you’re staring at a television screen or cellphone late at night? Apparently so, and when such activity is detected, the organ can throw your circadian rhythms out of whack, leaving you more susceptible to health problems.

That’s one of the takeaways from two new studies by University of California, Irvine scientists working in collaboration with the Institute for Research in Biomedicine in Barcelona, Spain.

The studies, published tod...

Read More

How Microbiome is disrupted during IBD: Human Microbiome Project

A chart showing interactions between human and gut microbial features during inflammatory bowel disease.
A depiction of interactions between human and gut microbial features during inflammatory bowel disease.

A new study led by researchers from Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard is the first to have observed the complex set of chemical and molecular events that disrupt the microbiome and trigger immune responses during flare-ups of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis.

While previous studies have cataloged microbial changes during IBD, the researchers in this study developed a unique biotechnology toolbox to understand why microbiomes change during IBD and how this provokes an unhealthy inflammatory reaction...

Read More

Synthetic Version of CBD treats Seizures in Rats

Hemp oil stock art
CBD from extracts of cannabis or hemp plants could be used to treat epilepsy and other conditions. UC Davis chemists have come up with a way to make a synthetic version of CBD and showed that it is as effective as herbal CBD in treating seizures in rats. (Getty images)

A synthetic, non-intoxicating analogue of cannabidiol (CBD) is effective in treating seizures in rats, according to research by chemists at the University of California, Davis.

The synthetic CBD alternative is easier to purify than a plant extract, eliminates the need to use agricultural land for hemp cultivation, and could avoid legal complications with cannabis-related products. The work was recently published in the journal Scientific Reports.

“It’s a much safer drug than CBD, with no abuse potential and doesn...

Read More

New Causes of Autism found in ‘Junk’ DNA

Figure 1
Analysis of the effects of noncoding mutations converges on brain-specific signals and neurodevelopmental processes

Neurodevelopmental condition can result from mutations in the noncoding regions of the human genome, research shows. Leveraging artificial intelligence techniques, researchers have demonstrated that mutations in so-called ‘junk’ DNA can cause autism. The study, published May 27 in Nature Genetics, is the first to functionally link such mutations to the neurodevelopmental condition.

The research was led by Olga Troyanskaya in collaboration with Robert Darnell. Troyanskaya is deputy director for genomics at the Flatiron Institute’s Center for Computational Biology (CCB) in New York City and a professor of computer science at Princeton University...

Read More