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Category Health/Medical
A New Way of Diagnosing and Treating Disease – without cutting Skin
May 19, 2019,
Health/Medical, Biology/Biotechnology
Newly identified Bacteria-killing Protein needs Vitamin A to work
May 16, 2019,
Health/Medical, Biology/Biotechnology
Highlights
Skin microbiota induces epidermal RELMα, which kills bacteria via membrane disruption
RELMα-deficient mice have altered skin microbiota and are more susceptible to infection
Dietary vitamin A is required for RELMα expression
RELMα is required for vitamin-A-dependent resistance to skin infection
People who have inadequate vitamin A in their diets are more susceptible to skin infection, yet how that vitamin affects skin immunity has been unclear. In a study published today, UT Southwestern researchers shed some light on that mystery by identifying a previously unknown bacteria-killing protein on the epidermis that requires the vitamin to work.
The researchers found that one protein in the resistin-like molecule (RELM) family – RELMα – acts as an antibiotic to rapidly kill...
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Low humidity increases influenza disease through caspase-1/11 activation. WT Mx1 mice or caspase-1/11 KO Mx1 mice were preconditioned at 10% and 50% RH for 5 d and challenged with aerosolized hvPR8 at 2 × 105pfu/mL for 15 min (n = 6 mice per group). (A and B) Weight loss was monitored for 14 d. Data are representative of four experiments and means ± SEM *P < 0.05; one-way ANOVA; Student’s t test.
Yale researchers have pinpointed a key reason why people are more likely to get sick and even die from flu during winter months: low humidity. While experts know that cold temperatures and low humidity promote transmission of the flu virus, less is understood about the effect of decreased humidity on the immune system’s defenses against flu infection.
The Yale research team, led by Ak...
Read MoreCommon Food Additive Found to Affect Gut Microbiota
May 14, 2019,
Health/Medical, Chemistry/Nanotechnology, Biology/Biotechnology
Impact of the food additive titanium dioxide (E171) on gut microbiota-host interaction. Frontiers in Nutrition, 2019
Titanium dioxide nanoparticles E171 may impact human health. University of Sydney research provides new evidence that nanoparticles, which are present in many food items, may have a substantial and harmful influence on human health. E171 is commonly used in high quantities in foods and some medicines as a whitening agent. Found in more than 900 food products such as chewing gum and mayonnaise, E171 is consumed in high proportion everyday by the general population.
Published in Frontiers in Nutrition, the mice study found that consumption of food containing E171 has an impact on the gut microbiota (defined by the trillions of bacteria that inhabit the gut) which coul...
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