Category Health/Medical

Why Getting Enough Sleep Reduces Cardiovascular Disease Risk

Images of plaque from the artery of a mouse model of atherosclerosis that experienced a normal sleeping pattern (left) and an image of arterial plaque from a mouse model that underwent sleep fragmentation (right). The amount of arterial plaque in the sleep-fragmented mouse is significantly larger.
Credit: Filip Swirski, Ph.D., Harvard Medical School

Sleep-modulating hormone hypocretin found to also control production of inflammatory cells. Getting enough sleep is key to good health, and studies have shown that insufficient sleep increases the risk of serious problems, including cardiovascular disease. Now Massachusetts General Hospital (MGH) investigators have discovered one way that sleep protects against the buildup of arterial plaques called atherosclerosis...

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Drug to Rejuvenate Muscle Cells


Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Elderly to feel fitter, faster and stronger. Researchers from The University of Texas Medical Branch at Galveston have developed a promising drug that has proven to significantly increase muscle size, strength and metabolic state in aged mice, according to a study just published in Biochemical Pharmacology.

As we age, our bodies increasingly lose the ability to repair and rebuild degenerating skeletal muscles. Beginning around age 35, muscle mass, strength and function continually decline as we get older. This can dramatically limit the ability of older adults to live fully active and independent lives.

“We identified a protein in m...

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Push-Up Capacity Linked with Lower Incidence of Cardiovascular Disease events among Men

Man doing push-ups
“Association Between Push-up Exercise Capacity and Future Cardiovascular Events Among Active Adult Men,” Justin Yang, Costas A. Christophi, Andrea Farioli, Dorothee M. Baur, Steven Moffat, Terrell W. Zollinger, Stefanos N. Kales, JAMA Network Open, February 15, 2019, doi: 10.1001./jamanetworkopen.2018.8341

Active, middle-aged men able to complete more than 40 push-ups had a significantly lower risk of cardiovascular disease (CVD) outcomes – including diagnoses of coronary artery disease and major events such as heart failure – during 10 years of follow-up compared with those who were able to do less than 10 push-ups during the baseline exam.

“Our findings provide evidence that push-up capacity could be an easy, no-cost method to help assess cardiovascular disease risk in almos...

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New Molecules Reverse Memory Loss linked to Depression, Aging

Image result for New molecules reverse memory loss linked to depression, aging

Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive ProfilesMolecular Neuropsychiatry, 2019; 1 DOI: 10.1159/000496086

New therapeutic molecules developed at Toronto’s Centre for Addiction and Mental Health (CAMH) show promise in reversing the memory loss linked to depression and aging.
These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models.

“Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging,” says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study.

What’s unique and p...

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