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    Category Health/Medical

    A boundary dance of Amyloid-beta stepping into Dementia

    January 1, 2019, Categories  Health/Medical, Biology/Biotechnology

    (a) An A-beta peptide that forms a beta-hairpin structure at the hydrophilic/hydrophobic interface. (b) View from the bottom of panel (a).
    Credit: ExCELLS/IMS

    Formation mechanism of the causative substances of Alzheimer’s disease revealed. Alzheimer’s disease is caused by aggregates of amyloid-beta peptides. This aggregation is accelerated at a cell membrane surface. The research group at ExCELLS revealed the reason of this phenomenon by molecular dynamics simulations and NMR experiments.

    Many proteins aggregate at higher concentrations and form spherical substances called oligomers and acicular substances called amyloid fibrils...

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    How Exercise Reduces Belly Fat in humans

    December 30, 2018, Categories  Biology/Biotechnology, Health/Medical

    This graphical abstract shows that in abdominally obese people, exercise-mediated loss of visceral adipose tissue mass requires IL-6 receptor signaling.
    CREDIT
    Wedell-Neergaard, Lehrskov, and Christensen, et al. / Cell Metabolism

    Some of you may have made a New Year’s resolution to hit the gym to tackle that annoying belly fat. But have you ever wondered how physical activity produces this desired effect? A signaling molecule called interleukin-6 plays a critical role in this process, researchers report December 27 in the journal Cell Metabolism.

    As expected, a 12-week intervention consisting of bicycle exercise decreased visceral abdominal fat in obese adults...

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    Salk Scientists find Genetic Signatures of Biological Aging

    December 27, 2018, Categories  Health/Medical, Biology/Biotechnology

    Fig. 1

    Predicting age from gene expression data. Rows from top to bottom show age prediction results for LDA Ensemble with 20-year age bins, elastic net, linear regression, and support vector regression

    Some people appear to be considerably younger or older than their chronological age. Genetic signatures that may help explain this have been discovered by scientists at the Salk Institute. The age-associated genetic patterns were found by analyzing skin cells from people of various ages, according to a study by Salk Institute scientists.

    Researchers then applied the results to detect genetic signs of accelerated aging in people with progeria, a disease that causes patients to appear far older than their chronological age...

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    Human Blood Cells can be directly Reprogrammed into Neural stem cells

    December 27, 2018, Categories  Health/Medical, Biology/Biotechnology


    Stem cells are considered to be the all-rounders of our tissues: they can multiply indefinitely and then — if they are pluripotent embryonic stem cells — generate all conceivable cell types.
    Credit: © M.C. Thier/DKFZ

    Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely in the culture dish and can represent an important basis for the development of regenerative therapies.

    Stem cells are considered to be the all-rounders of our tiss...

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