Category Health/Medical

Push-Up Capacity Linked with Lower Incidence of Cardiovascular Disease events among Men

Man doing push-ups
“Association Between Push-up Exercise Capacity and Future Cardiovascular Events Among Active Adult Men,” Justin Yang, Costas A. Christophi, Andrea Farioli, Dorothee M. Baur, Steven Moffat, Terrell W. Zollinger, Stefanos N. Kales, JAMA Network Open, February 15, 2019, doi: 10.1001./jamanetworkopen.2018.8341

Active, middle-aged men able to complete more than 40 push-ups had a significantly lower risk of cardiovascular disease (CVD) outcomes – including diagnoses of coronary artery disease and major events such as heart failure – during 10 years of follow-up compared with those who were able to do less than 10 push-ups during the baseline exam.

“Our findings provide evidence that push-up capacity could be an easy, no-cost method to help assess cardiovascular disease risk in almos...

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New Molecules Reverse Memory Loss linked to Depression, Aging

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Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive ProfilesMolecular Neuropsychiatry, 2019; 1 DOI: 10.1159/000496086

New therapeutic molecules developed at Toronto’s Centre for Addiction and Mental Health (CAMH) show promise in reversing the memory loss linked to depression and aging.
These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models.

“Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging,” says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study.

What’s unique and p...

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Platelet ‘Decoys’ Outsmart both Clots and Cancer

Platelet decoys (pink), unlike normal platelets, are not activated by collagen fibers (gray), making them an attractive option for antithrombotic and cancer treatment. Credit: Wyss Institute at Harvard University

Deactivated platelets offer a potential drug-free, reversible antiplatelet therapy. What do heart disease, stroke, sepsis, and cancer have in common, aside from being deadly diseases? They’re all linked to activated platelets. New research has created ‘decoy’ platelets that can both prevent blood clots and keep cancer from spreading.

Several antiplatelet drugs have been developed to combat platelet-related conditions, but their effects are not easily reversible, and patients taking these drugs are at risk of uncontrolled bleeding if injured...

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Role of Estrogen in controlling Type 2 Diabetes

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Dr. Guo (standing) with Wanbao Yang, a Ph.D. student in Guo’s lab at Texas A&M University. Yang was the second author of the study investigating the role of estrogen in control of glucose homeostasis. (Texas A&M AgriLife Research photo) Credit: Texas A&M AgriLife Research

The results of a recent study provide insights into the mechanism by which estrogen can decrease insulin resistance and the production of glucose, reducing incidences of Type 2 diabetes mellitus. The results of a recent Texas A&M University-led study provide insights into the mechanism by which estrogen can decrease insulin resistance and the production of glucose, reducing incidence of Type 2 diabetes mellitus.

The study, “Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription...

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