Category Health/Medical

New Pill can Deliver Insulin Through the Stomach

An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin.
Credit: Felice Frankel

An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 2 diabetes have to give themselves every day.

About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they could deliver enough insulin to lower blood sugar to levels comparable to those produced by injections given through skin. They also demonstrated that the device can be adapted to deliver other protein drugs.

“We are really hopeful that this new ty...

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This is a Neuron on Nicotine: Nicotine works inside cells to Reinforce Addiction


In this image, a biosensor is targeted to a cell’s endoplasmic reticulum and glows green in the presence of nicotine
Credit: Caltech/Lester laboratory

Newly developed sensors visually illustrate how nicotine affects cells from the inside out. When a person takes a puff on a cigarette, nicotine floods into the brain, latching onto receptors on the surface of neurons and producing feelings of happiness. But nicotine does not simply stay on the surface of cells – the drug actually permeates into neural cells and alters them from the inside out. Now, a team of scientists has developed a protein sensor that glows in the presence of nicotine, allowing the researchers to observe nicotine’s movements in cells and reveal more about the nature of nicotine addiction.

The work was led by Henry...

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Scientists develop 1st Fabric to Automatically Cool or Insulate depending on conditions

This new fabric being developed by University of Maryland scientists YuHuang Wang and Ouyang Min is the first textile to automatically change properties to trap or release heat depending on conditions.
Credit: Faye Levine, University of Maryland

Researchers have engineered a new fabric from synthetic yarn with a carbon nanotube coating that is activated by temperature and humidity, releasing heat in warm humid conditions and trapping heat when conditions are cool and dry. Under hot, humid conditions, the strands of yarn compact and activate the coating, which changes the way the fabric interacts with infrared radiation. They refer to the action as “gating” of infrared radiation, which acts as a tunable blind to transmit or block heat.

“This is the first technology that allows us to dyn...

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Laughter may be Best Medicine – for Brain Surgery

Illustration showing how an electrode was inserted into the cingulum bundle.
Credit: From Bijanki et al, J. Clin. Invest. (2019); Courtesy of American Society for Clinical Investigation

Effects of electrical stimulation of cingulum bundle. Neuroscientists at Emory University School of Medicine have discovered a focal pathway in the brain that when electrically stimulated causes immediate laughter, followed by a sense of calm and happiness, even during awake brain surgery. The effects of stimulation were observed in an epilepsy patient undergoing diagnostic monitoring for seizure diagnosis. These effects were then harnessed to help her complete a separate awake brain surgery two days later.

The behavioral effects of direct electrical stimulation of the cingulum bundle, a white matte...

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