Category Health/Medical

Peeling off Slimy Biofilms like Old Stickers

Researchers at Princeton have found a new method to remove biofilms, bacterial mats that can cause infections and foul industrial equipment. The method, using peeling, contrasts with scraping or mechanically dislodging biofilms, which can leave patches that regrow and recontaminate.
Credit: Yan et al./Princeton University

Slimy, hard-to-clean bacterial mats called biofilms cause problems ranging from medical infections to clogged drains and fouled industrial equipment. Now, researchers at Princeton have found a way to cleanly and completely peel off these notorious sludges.

By looking at the films from a mechanical engineering perspective, as well as a biological one, the researchers showed that water penetrating the junction between biofilms and surfaces, coupled with gentle peeling...

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Ingestible Capsule can be controlled Wirelessly

Electronic pill can relay diagnostic information or release drugs in response to smartphone commands. Researchers at MIT, Draper, and Brigham and Women’s Hospital have designed an ingestible capsule that can be controlled using Bluetooth wireless technology. The capsule, which can be customized to deliver drugs, sense environmental conditions, or both, can reside in the stomach for at least a month, transmitting information and responding to instructions from a user’s smartphone.

The capsules, manufactured using 3D-printing technology, could be deployed to deliver drugs to treat a variety of diseases, partic...

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New Discoveries Predict Ability to Forecast Dementia from Single Molecule


A single tau monomer encodes different assembly conformations that each leads to distinct patterns of pathology.
Credit: UT Southwestern

Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases.

A new study from UT Southwestern shows that single toxic tau proteins that stick together and spread degeneration across the brains of dementia patients have different shapes. The folds of these molecules hold information that could help diagnose – and perhaps one day treat – neurodegeneration in its earliest stages.

The finding comes from a team of scientists appointed this month to a newly c...

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Regrowing Damaged Nerves Hinges on Shutting Down Key Genes


Mouse neurons are shown with the cell bodies in the center and long tendrils radiating outward. Valeria Cavalli, PhD, of Washington University School of Medicine in St. Louis, used such neurons to study how cells regrow after injury. Her findings could one day lead to better treatments for spinal cord injury.

Injured neurons temporarily revert to immature state. Neurons in the brain and spinal cord don’t grow back after injury, unlike those in the rest of the body. Cut your finger, and you’ll probably be back to using it in days or weeks; slice through your spinal cord, and you likely will never walk again.

Now, working in mice, researchers at Washington University School of Medicine in St...

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