Category Health/Medical

Simple Drug Combination creates new Neurons from Neighboring cells

A simple treatment using four small molecules converts human astrocytes – a common type of cells in the nervous system – into new neurons, which develop complex structures after 4 months, as pictured. Credit: Gong Chen Lab, Penn State
A simple treatment using four small molecules converts human astrocytes – a common type of cells in the nervous system – into new neurons, which develop complex structures after 4 months, as pictured. Credit: Gong Chen Lab, Penn State

A simple drug cocktail that converts cells neighboring damaged neurons into functional new neurons could potentially be used to treat stroke, Alzheimer’s disease, and brain injuries. A team of researchers at Penn State identified a set of four, or even three, molecules that could convert glial cells – which normally provide support and insulation for neurons – into new neurons. A paper describing the approach appears online in the journal Stem Cell Reports on February 7, 2019.

“The biggest problem for brain repair is that neurons don’t regenerate aft...

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New Pill can Deliver Insulin Through the Stomach

An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin.
Credit: Felice Frankel

An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 2 diabetes have to give themselves every day.

About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they could deliver enough insulin to lower blood sugar to levels comparable to those produced by injections given through skin. They also demonstrated that the device can be adapted to deliver other protein drugs.

“We are really hopeful that this new ty...

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This is a Neuron on Nicotine: Nicotine works inside cells to Reinforce Addiction


In this image, a biosensor is targeted to a cell’s endoplasmic reticulum and glows green in the presence of nicotine
Credit: Caltech/Lester laboratory

Newly developed sensors visually illustrate how nicotine affects cells from the inside out. When a person takes a puff on a cigarette, nicotine floods into the brain, latching onto receptors on the surface of neurons and producing feelings of happiness. But nicotine does not simply stay on the surface of cells – the drug actually permeates into neural cells and alters them from the inside out. Now, a team of scientists has developed a protein sensor that glows in the presence of nicotine, allowing the researchers to observe nicotine’s movements in cells and reveal more about the nature of nicotine addiction.

The work was led by Henry...

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Scientists develop 1st Fabric to Automatically Cool or Insulate depending on conditions

This new fabric being developed by University of Maryland scientists YuHuang Wang and Ouyang Min is the first textile to automatically change properties to trap or release heat depending on conditions.
Credit: Faye Levine, University of Maryland

Researchers have engineered a new fabric from synthetic yarn with a carbon nanotube coating that is activated by temperature and humidity, releasing heat in warm humid conditions and trapping heat when conditions are cool and dry. Under hot, humid conditions, the strands of yarn compact and activate the coating, which changes the way the fabric interacts with infrared radiation. They refer to the action as “gating” of infrared radiation, which acts as a tunable blind to transmit or block heat.

“This is the first technology that allows us to dyn...

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