Category Health/Medical

In young muscle, high levels of Klotho maintain mitochondia, which aids regeneration after injury. Age-related declines of Klotho lead to mitochondrial damage and impaired healing.
CREDIT
Sahu et al. (2018), Nature Communications

One of the downsides to getting older is that skeletal muscle loses its ability to heal after injury. New research from the University of Pittsburgh implicates the so-called “longevity protein” Klotho, both as culprit and therapeutic target.

The paper, published this week in Nature Communications, showed that, in young animals, Klotho expression soars after a muscle injury, whereas in old animals, it remains flat...

Support for the Safe Use of Zinc Oxide Nanoparticle Sunscreens: Lack of Skin Penetration or Cellular Toxicity after Repeated Application in Volunteers. Journal of Investigative Dermatology, 2018; DOI: 10.1016/j.jid.2018.08.024

It’s safe to slap on the sunscreen this summer – in repeated doses – despite what you have read about the potential toxicity of sunscreens. A new study led by the University of Queensland (UQ) and University of South Australia (UniSA) provides the first direct evidence that zinc oxide nanoparticles used in sunscreen neither penetrate the skin nor cause cellular toxicity after repeated applications.

The research, published this week in the Journal of Investigative Dermatology, refutes widespread claims among some public advocacy groups – and a growing belief among con...

Chase Cornelison is a post-doctoral researcher at Virginia Tech and lead author of an article published in Scientific Reports that details a solution to stopping the spread of glioblastoma in the brain.

A team of researchers may have found a solution to stopping the spread of glioblastoma with a new drug and cancer treatment method. In people who have glioblastoma, the deadliest form of brain cancer, this fluid has a much higher pressure, causing it to move fast and forcing cancer cells to spread. And a common cancer therapy, which inserts a drug directly into the tumor with a catheter, can make this fluid move even faster.

A team of researchers at Virginia Tech, led by Jennifer Munson, an assistant professor in the Department of Biomedical Engineering and Mechanics in the College of Engin...

Electron microscope image of the porous hydrogel. Credit: UNH

Wound healing can be complex and challenging, especially when a patient has other health obstacles that seriously impede the process. Often injectable hydrogels are applied to irregular shaped wounds, like diabetic ulcers, to help form a temporary matrix, or structure, to keep the wound stable while cells rejuvenate. The caveat is that current hydrogels are not porous enough and do not allow neighboring cells to pass through toward the wound to help it mend.

“While valuable for helping patients, current hydrogels have limited clinical efficacy,” said Kyung Jae Jeong, assistant professor of chemical engineering at UNH. “We discovered a simple solution to make the hydrogels more porous and therefore help to speed up the healing...