Category Health/Medical

The NLRP3 inflammasome (green) is expressed by immune cells (red) in the brains of people with Parkinson’s disease.

A promising new therapy to stop Parkinson’s disease in its tracks has been developed at The University of Queensland. UQ Faculty of Medicine researcher Associate Professor Trent Woodruff said the team found that a small molecule, MCC950, stopped the development of Parkinson’s in several animal models. “We have used this discovery to develop improved drug candidates and hope to carry out human clinical trials in 2020,” Dr Woodruff said.

“Parkinson’s disease is the second-most common neurodegenerative disease worldwide, with 10 million sufferers, whose control of body movements is affected.
“The disease is characterised by the loss of brain cells that produce dopamine, which ...

“Having a better understanding of the father’s biological role will be obviously important for the offspring, but also potentially for the mother.”

A decade of data documenting live births in the United States links babies of older fathers with a variety of increased risks at birth, including low birth weight and seizures, according to a new study by researchers at the Stanford University School of Medicine. The data even suggest that the age of the father can sway the health of the mother during pregnancy, specifically her risk for developing diabetes...

STIMO study participant David Mzee is now able to take a few steps of his own. He was totally paraplegic after a sports accident.
Credit: EPFL / Jean-Baptiste Mignardot

Targeted neurotechnology restores walking in humans with spinal cord injury. Three paraplegics who sustained cervical spinal cord injuries many years ago are now able to walk with the aid of crutches or a walker thanks to new rehabilitation protocols that combine targeted electrical stimulation of the lumbar spinal cord and weight-assisted therapy.

This latest study, called STIMO (STImulation Movement Overground), establishes a new therapeutic framework to improve recovery from spinal cord injury. All patients involved in the study recovered voluntary control of leg muscles that had been paralyzed for many years...

Aggregated alpha-synuclein in the neurons of the appendix.
Credit: Courtesy of Viviane Labrie | Van Andel Research Institute

Appendix acts as a reservoir for disease-associated proteins; appendectomy lowers the risk of developing Parkinson’s. Removing the appendix early in life reduces the risk of developing Parkinson’s disease by 19 to 25%, according to the largest and most comprehensive study of its kind, published today in Science Translational Medicine.

The findings also solidify the role of the gut and immune system in the genesis of the disease, and reveal that the appendix acts as a major reservoir for abnormally folded alpha-synuclein proteins, which are closely linked to Parkinson’s onset and progression.

“Our results point to the appendix as a site of origin for Parkinson’s and pr...