Category Health/Medical

Orthogonal programming of matrix stiffness and geometry via oxygen inhibition-assisted stereolithography.

University of Colorado Boulder engineers have developed a 3D printing technique that allows for localized control of an object’s firmness, opening up new biomedical avenues that could one day include artificial arteries and organ tissue. The study, which was recently published in the journal Nature Communications, outlines a layer-by-layer printing method that features fine-grain, programmable control over rigidity, allowing researchers to mimic the complex geometry of blood vessels that are highly structured and yet must remain pliable.

The findings could one day lead to better, more personalized treatments for those suffering from hypertension and other vascular diseases...

Left: A simplified representation of a small part of the brain: neurons receive, process and transmit signals through synapses. Right: a crossbar array, which is a possible architecture of how this could be realized with devices. The memristors, like synapses in the brain, can change their conductivity so that connections can be weakened and strengthened.
Credit: Spintronics of Functional Materials group, University of Groningen

Computer bits are binary, with a value of 0 or 1. By contrast, neurons in the brain can have all kinds of different internal states, depending on the input that they received. This allows the brain to process information in a more energy-efficient manner than a computer...

Scientists are developing a new approach to restore the hearing loss.
Credit: © 9nong / Fotolia

Researchers have taken an important step toward what may become a new approach to restore the hearing loss. In a new study, out today in the European Journal of Neuroscience, scientists have been able to regrow the sensory hair cells found in the cochlea – a part of the inner ear – that converts sound vibrations into electrical signals and can be permanently lost due to age or noise damage.

Hearing impairment has long been accepted as a fact of life for the aging population – an estimated 30 million Americans suffer from some degree of hearing loss...

A metal-free ribonucleotide reductase–an enzyme required for DNA replication–from bacterial pathogens uses a post-translationally modified amino acid (pictured) to initiate an essential DNA biosynthesis reaction. The modification (indicated by arrow) is essential for initiation of ribonucleotide reduction. This metal-free enzyme could allow microbes associated with strep throat and pneumonia infections to more effectively proliferate during iron/manganese limitation imposed by the human immune system.
Credit: Gavin Palowitch, Penn State

A new study shows that some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA using a ribonucleotide reductase enzyme that does not require a metal ion cofactor...