Category Health/Medical

In skin biopsies from the legs of healthy people (left) there are abundant sensory nerve fibers (green) but few macrophages (red). Meanwhile, in biopsies from patients with pain due to diabetic neuropathy (right), macrophages (red) surround degenerating nerve fibers (green).
Credit: Mohopatra lab

Researchers have found that inhibiting a receptor on macrophages may help relieve pain in some patients, particularly those with chronic neuropathic pain, such as those with conditions such as diabetic neuropathy. Recently, a non-opioid, investigational drug called EMA401 has shown promise as a treatment for lingering nerve pain following shingles infection...

Mechanism of action of the identified STING antagonists.

Scientists have discovered two small-molecule compound series that can effectively block a central pathway of the innate immune system, offering a promising new way for treating autoinflammatory diseases. As a key strategy to sense the presence of pathogens, the cells of the innate immune system use receptors that can identify microbial DNA and in turn activate a protein called STING (STimulator of Interferon Genes). Once activated, STING turns on genes that help cells fight off the infecting pathogen.

Nonetheless, the innate immune system can turn against the body itself, causing a number of diseases, which are referred to as autoinflammatory...

Voxel-based morphometry (VBM) F-test result comparing three subjective age (SA) groups (younger, same and older) in Korean Social Life, Health and Aging Project (KSHAP) data (n = 68). Significant group differences in regional gray matter (GM) density are visualized (p < 0.01, uncorrected, k > 500). Post hoc pairwise t-tests of the three groups indicated whether family-wise error (FWE)-corrected (voxel-level or cluster-level p < 0.05) voxels were included in the initially identified F-test clusters.

The first study to link subjective age to biological age shows that elderly people who feel younger have less signs of brain aging. While everyone gets older, not everyone feels their age. A recent study finds that such feelings, called subjective age, may reflect brain aging...