Category Health/Medical

Image: super resolution image of α-synuclein in mitochondria of neuron (left) and single molecule TIRF image of individual α-synuclein aggregates (right). Credit: Mathew Horrocks

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson’s disease. The study adds to our growing understanding of the causes of Parkinson’s and other neurodegenerative diseases, and could influence drug design in the future.

For years, scientists have known that Parkinson’s disease is associated with a build-up of alpha-synuclein protein inside brain cells. But how these protein clumps cause neurons to die was a mystery...

The regenerative bandage promotes cell spreading and proliferation. The green spots are live cells entrapped in the hydrogel and stained with Calcein-AM. Credit: Ameer Research Lab, Northwestern University

Shape-conforming hydrogel leverages the body’s own healing mechanisms rather than releasing drugs or biologics. Researchers have developed a new device, called a regenerative bandage, that quickly heals painful, hard-to-treat sores without using drugs. During head-to-head tests, the new bandage healed diabetic wounds 33% faster than one of the most popular bandages currently on the market.

“The novelty is that we identified a segment of a protein in skin that is important to wound healing, made the segment and incorporated it into an antioxidant molecule that self-aggregates at body temp...

Therepi’s reservoir, which would attach directly to the damaged heart tissue, is placed on a dime for size reference and connected to a self-sealing subcutaneous port. Credit: Nature Biomedical Engineering, Whyte et al.; Creative Commons Attribution Non-Commercial No Derivatives license

A team of researchers is hoping to halt the progression from heart attack to heart failure with a small device called ‘Therepi.’ The device contains a reservoir that attaches directly to the damaged heart tissue. A refill line connects the reservoir to a port on or under the patient’s skin where therapies can be injected either by the patient or a healthcare professional.

After a patient has a heart attack, a cascade of events leading to heart failure begins...

This is an image of ‘surgery in a pill’ in the intestine. Credit: Brigham and Women’s Hospital and Randal Mckenzie

Over the last decade, bariatric surgeons have made strides in performing weight loss surgery that not only reverses obesity but can also reverse type 2 diabetes in patients with both conditions. Despite dramatic improvements in quality of life and diabetes remission, the number of patients who pursue surgery remains relatively low, according to Ali Tavakkoli, MD, co-director of the Center for Weight Management and Metabolic Surgery at BWH...