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    Category Health/Medical

    The Na/K-ATPase Oxidant Amplification Loop Regulates Aging

    June 27, 2018, Categories  Health/Medical, Biology/Biotechnology

    Effects of pNaKtide on adipocyte phenotype, senescence, and apoptosis in C57Bl6 aging mice. (A) H&E staining in visceral adipose tissue. Images taken with 40X objective lens; scale bar represents 100 µm. Arrows mark “crown like structures” indicative of inflammation. (B) Quantitative analysis of adipocytes area in visceral adipose tissue. (C) Representative images of TUNEL assay with quantification in C57B16 aging mice. Images taken with 40X objective lens; scale bar represents 25 µm. (D–F) qRT-PCR analysis of ApoJ, p21 and PPARγ in C57Bl6 aging mice with GAPDH as a loading control. Y, young; Y + P, young + pNaKtide; OB, old baseline; O, old; O + P, old + pNaKtide; O + WD, old + western diet; O + WD + P, old + western diet + pNaKtide. N = 8/group, *p < 0.05, **p < 0.01 vs Y, #p < 0.05, ##p < 0.01 vs O, &p < 0.05, &&p < 0.01 vs O + WD.

    Effects of pNaKtide on adipocyte phenotype, senescence, and apoptosis in C57Bl6 aging mice. (A) H&E staining in visceral adipose tissue. Images taken with 40X objective lens; scale bar represents 100 µm. Arrows mark “crown like structures” indicative of inflammation. (B) Quantitative analysis of adipocytes area in visceral adipose tissue. (C) Representative images of TUNEL assay with quantification in C57B16 aging mice. Images taken with 40X objective lens; scale bar represents 25 µm. (D–F) qRT-PCR analysis of ApoJ, p21 and PPARγ in C57Bl6 aging mice with GAPDH as a loading control. Y, young; Y + P, young + pNaKtide; OB, old baseline; O, old; O + P, old + pNaKtide; O + WD, old + western diet; O + WD + P, old + western diet + pNaKtide. N = 8/group, *p < 0.05, **p < 0...

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    Delivering Insulin in a Pill

    June 26, 2018, Categories  Health/Medical, Biology/Biotechnology

    Oral delivery method could dramatically transform the way in which diabetics keep their blood sugar levels in check. Credit: Harvard SEAS

    Oral delivery method could dramatically transform the way in which diabetics keep their blood sugar levels in check. Credit: Harvard SEAS

    Technique could replace daily injections for diabetics. For millions of people living with type 1 diabetes, a painful needle prick once or twice daily is currently the only option for delivering the insulin that their bodies cannot produce on their own. Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed an oral delivery method that could dramatically transform the way in which diabetics keep their blood sugar levels in check.

    Not only does oral delivery of insulin promise to improve the quality of life for up to 40 million people with type 1 diabetes worldwide, it could also mitigate many of t...

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    Scientists Discover How Antiviral Gene Works

    June 26, 2018, Categories  Health/Medical, Biology/Biotechnology

    Viperin converts CTP to ddhCTP, which in vivo, acts as an inhibitor of viral replication machinery.

    It’s been known for years that humans and other mammals possess an antiviral gene called RSAD2 that prevents a remarkable range of viruses from multiplying. Now, researchers at Albert Einstein College of Medicine, part of Montefiore, have discovered the secret to the gene’s success: The enzyme it codes for generates a compound that stops viruses from replicating. The newly discovered compound, described in today’s online edition of Nature, offers a novel approach for attacking many disease-causing viruses.

    “Nature has given us a template for creating a powerful and safe antiviral compound,” says study leader Steven C. Almo, Ph.D...

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    Our Intestinal Microbiome Influences Metabolism – through the Immune System

    June 23, 2018, Categories  Health/Medical, Biology/Biotechnology

    The fruit fly intestine shares much of the same physiology of the human intestine, just simpler and on a smaller scale. Credit: Adam Wong, PhD. Modified from Disease Models & Mechanisms. doi: 10.1242/dmm.023408.

    The fruit fly intestine shares much of the same physiology of the human intestine, just simpler and on a smaller scale. Credit: Adam Wong, PhD. Modified from Disease Models & Mechanisms. doi: 10.1242/dmm.023408.

    Study teases out how ‘good bacteria’ keep us metabolically fit. The innate immune system, our first line of defense against bacterial infection, has a side job that’s equally important: fine-tuning our metabolism. The study, led by Paula Watnick, MD, PhD, of the Division of Infectious Diseases at Boston Children’s Hospital, reveals that innate immune pathways, best known as our first line of defense against bacterial infection, have a side job that’s equally important.

    In the intestine, digestive cells use an innate immune pathway to respond to harmful bacteria...

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