Category Health/Medical

Extracellular vesicle-like metal-organic framework nanoparticles are developed for the intracellular delivery of biofunctional proteins. The biomimetic nanoplatform can protect the protein cargo and overcome various biological barriers to achieve systemic delivery and autonomous release. Credit: Zheng Lab/Penn State

A biomimetic nanosystem can deliver therapeutic proteins to selectively target cancerous tumors, according to a team of Penn State researchers. Using a protein toxin called gelonin from a plant found in the Himalayan mountains, the researchers caged the proteins in self-assembled metal-organic framework (MOF) nanoparticles to protect them from the body’s immune system...

Planarian flatworm adult stem cells known as neoblasts can be clustered based on their gene expression profiles (left panel). A neoblast subpopulation termed Nb2 expresses the cell membrane protein TSPAN-1 (center panel, a representative Nb2 cell with TSPAN-1 protein shown in green and DNA in blue). Nb2 neoblasts can repopulate stem cell-depleted animals (right panel, representative animals at different time points after Nb2 single-cell transplants). Credit: Sánchez Alvarado Lab

Researchers at the Stowers Institute for Medical Research have captured the one cell that is capable of regenerating an entire organism...

Shown are cross-sectional ultrasound images of coronary arteries from patients enrolled in the study. Plaque buildup (colored areas) in an artery from a patient that lacks sensitivity to red meat allergen (left) is much lower than plaque levels in an artery from a patient with sensitivity to red meat allergen (right). Credit: Courtesy of Angela Taylor, M.D., University of Virginia Health System

A team of researchers says it has linked sensitivity to an allergen in red meat to the buildup of plaque in the arteries of the heart. While high saturated fat levels in red meat have long been known to contribute to heart disease for people in general, the new finding suggests that a subgroup of the population may be at heightened risk for a different reason – a food allergen...

MIT engineers have created soft, 3-D-printed structures whose movements can be controlled with a wave of a magnet, much like marionettes without the strings. Credit: Felice Frankel

New printing technique could be used to develop remotely controlled biomedical devices. MIT engineers have created soft, 3D-printed structures whose movements can be controlled with a wave of a magnet. The menagerie of structures that can be magnetically manipulated includes a smooth ring that wrinkles up, a long tube that squeezes shut, a sheet that folds itself, and a spider-like “grabber” that can crawl, roll, jump, and snap together fast enough to catch a passing ball. It can even be directed to wrap itself around a small pill and carry it across a table.

The researchers fabricated each structure from a new ...