Category Health/Medical

Long-sought Structure of Telomerase Paves way for New Drugs for Aging, Cancer

Shown is the space-filling model of human telomerase holoenzyme structure determined by cryo-electron microscopy (cryo-EM). Telomerase catalyzes the synthesis of telomeric DNA (green) at the ends of chromosomes (blue) to compensate for the loss of telomeres during genome replication. The structure comprises two lobes with distinct functionalities: the catalytic core (purple) responsible for DNA synthesis and an H/ACA ribonucleoprotein lobe (cyan, teal and light green) important for telomerase biogenesis and localization to the Cajal body (red dots and lower left in closeup). Given that telomerase regulation is implicated in cancer and aging, this first architectural visualization of human telomerase represents an important breakthrough in the telomerase field and telomerase-based therapeutic design. Credit: Janet Iwasa

Shown is the space-filling model of human telomerase holoenzyme structure determined by cryo-electron microscopy (cryo-EM). Telomerase catalyzes the synthesis of telomeric DNA (green) at the ends of chromosomes (blue) to compensate for the loss of telomeres during genome replication. The structure comprises two lobes with distinct functionalities: the catalytic core (purple) responsible for DNA synthesis and an H/ACA ribonucleoprotein lobe (cyan, teal and light green) important for telomerase biogenesis and localization to the Cajal body (red dots and lower left in closeup)...

Read More

3D Print Electronics and Cells Printed Directly on Skin

One of the key innovations of the new 3-D-printing technique on skin is that the printer uses computer vision to track and adjust to movements in real-time. Credit: McAlpine group, University of Minnesota

One of the key innovations of the new 3-D-printing technique on skin is that the printer uses computer vision to track and adjust to movements in real-time. Credit: McAlpine group, University of Minnesota

Groundbreaking technology could help soldiers on the battlefield and people with skin disorders. In a groundbreaking new study, researchers at the University of Minnesota used a customized, low-cost 3D printer to print electronics on a real hand for the first time. The technology could be used by soldiers on the battlefield to print temporary sensors on their bodies to detect chemical or biological agents or solar cells to charge essential electronics.

Researchers also successfully printed biological cells on the skin wound of a mouse...

Read More

3D-printed Food could change how we Eat

A: Food materials are pulverized under ultra-low temperature close to -100 degrees Celsius. B: Micro-sized food materials are reconstructed into a porous film-shaped material by jetting bonding an agent under optimized water content and heat conditions. The process to build film-type materials is repeated layer by layer to form to a three-dimensional food block. C: The exterior of foods and internal microstructure of a food block with specific porosity is designed to give texture with controlled human body absorption while eating and ingesting. Credit: Jin-Kyu Rhee, Ewha Womans University

A: Food materials are pulverized under ultra-low temperature close to -100 degrees Celsius. B: Micro-sized food materials are reconstructed into a porous film-shaped material by jetting bonding an agent under optimized water content and heat conditions. The process to build film-type materials is repeated layer by layer to form to a three-dimensional food block. C: The exterior of foods and internal microstructure of a food block with specific porosity is designed to give texture with controlled human body absorption while eating and ingesting. Credit: Jin-Kyu Rhee, Ewha Womans University

Researchers 3D print food with customized texture and body absorption characteristics...

Read More

Scientists Unearth Vital Link between Fat, Immunity and Heat Regulation

Immune cells (or gd T cells) swarm around fat cells (adipocytes) in fat tissue to regulate their lipid burning vs storage. Credit: Lydia Lynch, Trinity College Dublin

Immune cells (or gd T cells) swarm around fat cells (adipocytes) in fat tissue to regulate their lipid burning vs storage. Credit: Lydia Lynch, Trinity College Dublin

Scientists have just made a surprising discovery involving fat and special immune cells that live within it – it turns out that ‘gd T cells’ are the key cogs in the biological wheel that regulates our body heat and protects us against cold shock. The discovery thus reveals a peculiar and previously unknown aspect of the immune system – as well as driving our response to infection, it also plays a role in regulating our metabolism. In addition, this discovery has put the spotlight on a potential new target for therapies designed to help individuals either lose or gain weight.

There are two quite distinct types of fat – white a...

Read More