Category Health/Medical

Human intestinal organoids (HIOs) generated in the hydrogel matrix differentiate into mature intestinal tissue and present specialized human intestinal cell types, such as enteroendocrine cells (CHGA; red), after transplantation into an animal. Credit: Ricardo Cruz-Acuña, Georgia Tech

By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids – made from human pluripotent stem cells – researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD)...

Koji Atarashi et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation, Science (2017). DOI: 10.1126/science.aan4526 Credit: CC0 Public Domain

An international team has found evidence that suggests certain types of oral bacteria may cause or exacerbate bowel disorders. In their paper published in the journal Science, the group describes testing the impact of introducing bacteria found in the mouths of humans to mice models. Xuetao Cao with the Chinese Academy of Medical Sciences offers a Perspective piece on the work done by the team in the same journal issue and suggests that the work might one day lead to the development of new kinds of treatments for common bowel disorders.

Bowel disorders such as irritable bowel syndrome, IBS, ulcerative ...

The system uses a commercial smartphone to acquire and interpret real-time images of an enzymatic amplification reaction that takes place in a silicon microfluidic chip that generates green fluorescence and displays a visual read-out of the test. The system is composed of an unmodified smartphone and a portable 3-D-printed cradle that supports the optical and electrical components, and interfaces with the rear-facing camera of the smartphone. Credit: Micro & Nanotechnology Laboratory, University of Illinois at Urbana-Champaign

A multidisciplinary group that includes the University of Illinois at Urbana-Champaign and the University of Washington at Tacoma has developed a novel platform to diagnose infectious disease at the point-of-care, using a smartphone as the detection instrument in con...

Approximate number of driver mutations needed to cause cancer by area of the body

The results show the number of mutations driving cancer varies considerably across different cancer types. For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumours across 29 cancer types. Researchers from the Wellcome Trust Sanger Institute and their collaborators adapted a technique from the field of evolution to confirm that, on average, one to ten driver mutations are needed for cancer to emerge.

In the future, such approaches could be used in the clinic to identify which few mutations in an individual patient are driving his or her cancer, from amongst the thousands of mutations present...