Category Health/Medical

Structural characterization of retrocyclin. (a) CD spectrum demonstrating the similarity in structure between retrocyclin and RTD-1, both at 0.5 mg/ml in a 1:1 mixture of trifluoroethanol in PBS at pH 7.4. (b) A hypothetical model of retrocyclin made by templating its sequence on the backbone of a similar peptide from porcine neutrophils, protegrin-1 (PDB accession code: 1PG1). (c) A cartoon version of b, wherein arginines are black, cysteines are gray, and the other residues are identified by single letter code. (d) A similar cartoon of rhesus RTD-1, indicating the similarity in structure with retrocyclin.

New research in the Journal of Leukocyte Biology identifies potential protective agent against flu infection...

Zinc rich food items

Study may provide a road map for treatment and prevention. Zinc supplements can significantly inhibit the proliferation of esophageal cancer cells, according to a new study. Previous studies had shown that zinc is essential for maintaining human health and protects the esophagus from cancer. However, it has never been fully understood why zinc has the ability to prevent cancer in the esophagus.

In this study, a team led by Zui Pan, an associate professor of nursing at UTA’s College of Nursing and Health Innovation and a noted esophageal cancer researcher, discovered that zinc selectively halts the growth of cancer cells but not normal esophageal epithelial cells...

New Application of Old Material: Chinese Traditional Ink for Photothermal Therapy of Metastatic Lymph Nodes. ACS Omega, 2017; 2 (8): 5170 DOI: 10.1021/acsomega.7b00993

For hundreds of years, Chinese calligraphers have used a plant-based ink to create beautiful messages and art. Now, one group reports in ACS Omega that this ink could noninvasively and effectively treat cancer cells that metastasize, to lymph nodes. Photothermal therapy (PTT) is an emerging noninvasive treatment option in which nanomaterials are injected and accumulate in cancer cells. A laser heats up the nanomaterials, and this heat kills the cells. Many of these nanomaterials are expensive, difficult-to-make and toxic...

ELV-N32 and ELV-N34 diminish NVU disruption and reduce brain infarction after ischemic stroke.

A new class of molecules in the brain that synchronize cell-to-cell communication and neuroinflammation/ immune activity in response to injury or diseases has been found. Elovanoids (ELVs) are bioactive chemical messengers made from omega-3 very long chain polyunsaturated fatty acids (VLC-PUFAs,n-3). They are released on demand when cells are damaged or stressed.

“Although we knew about messengers from omega-3 fatty acids such as neuroprotectin D1 (22 carbons) before, the novelty of the present discovery is that elovanoids are made of 32 to 34 carbon atoms in length,” notes Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans...