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    Category Health/Medical

    HIIT releases Endorphins in the Brain

    August 25, 2017, Categories  Health/Medical, Biology/Biotechnology

    High-intensity interval training triggers endorphin release in the brain. Photo: Turku PET Centre

    High-intensity interval training triggers endorphin release in the brain. Photo: Turku PET Centre

    Finnish researchers at the University of Turku have revealed that exercise-induced endorphin release in the brain depends on the intensity of the exercise. Endorphin release induced by exercise may be an important mechanism which affects exercise motivation and maintenance of regular physical activity. The popular high-intensity interval training (HIIT) leads to endorphin release in the brain, which might alleviate the physical and emotional stress caused by the high-intensity exercise. A less demanding, traditional one-hour aerobic exercise does not cause similar endorphin release.

    In the study, HIIT significantly increased the release of endorphins and other opioid peptides in the brain area...

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    New Light on Link between Gut Bacteria and Anxiety

    August 25, 2017, Categories  Health/Medical, Biology/Biotechnology

    GF male mice display dysregulated network of miRNA expression in the amygdala and PFC. a Schematic representation of experimental design. b Donut plot representing the number of increased and decreased miRNA in the amygdala (outer plot) and PFC (inner plot) when comparing CON vs GF mice. c Volcano plot representing fold change against significance (P < 0.05) between CON and GF mice in the amygdala and PFC. d Venn diagram reporting overlapping differentially regulated miRNA between all three experimental groups in the amygdala representing the effect of colonization of GF mice on miRNAs. e Represents the impact of colonization of GF mice in the PFC. f Number of miRNAs by name that are normalized by colonization and common in both brain regions. g Number of microRNAs that are commonly dysregulated in both brain regions. Highlighted in red are those that are oppositely regulated in both brain regions

    GF male mice display dysregulated network of miRNA expression in the amygdala and PFC. a Schematic representation of experimental design. b Donut plot representing the number of increased and decreased miRNA in the amygdala (outer plot) and PFC (inner plot) when comparing CON vs GF mice. c Volcano plot representing fold change against significance (P < 0.05) between CON and GF mice in the amygdala and PFC. d Venn diagram reporting overlapping differentially regulated miRNA between all three experimental groups in the amygdala representing the effect of colonization of GF mice on miRNAs. e Represents the impact of colonization of GF mice in the PFC. f Number of miRNAs by name that are normalized by colonization and common in both brain regions...

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    Enzyme Produced in Liver Promotes Obesity, Fatty Liver Disease and Insulin Resistance

    August 24, 2017, Categories  Health/Medical, Biology/Biotechnology

    NAFLD patients have augmented plasma DPP4 activity. • Hepatocyte-specific DPP4 overexpression in mice. (1) promotes fatty liver disease. (2) induces hepatic insulin resistance. (3) reduces systemic levels of active GLP-1. (4) enhances adipose tissue expansion and inflammation.

    NAFLD patients have augmented plasma DPP4 activity.
    •Hepatocyte-specific DPP4 overexpression in mice.
    (1) promotes fatty liver disease.
    (2) induces hepatic insulin resistance.
    (3) reduces systemic levels of active GLP-1.
    (4) enhances adipose tissue expansion and inflammation.

    In mice given a high-fat diet, an increased production of the enzyme DPP4* by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance. These were the findings of a current study by DZD-researchers in Potsdam and Tübingen...

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    High levels of ‘Good’ cholesterol linked to Excessive Mortality

    August 23, 2017, Categories  Health/Medical, Biology/Biotechnology

    HDL cholesterol and risk of all-cause mortality in the general population. Based on 52 268 men and 64 240 women from the Copenhagen General Population Study and the Copenhagen City Heart Study combined. Hazard ratio (solid line) and 95% confidence interval (dashed lines) from age and study adjusted Cox regression using restricted cubic splines. The concentration of HDL cholesterol associated with lowest mortality was used as reference. The light blue area indicates the distribution of HDL cholesterol concentrations in men and women. CI, confidence interval; HDL, high-density lipoprotein.

    HDL cholesterol and risk of all-cause mortality in the general population. Based on 52 268 men and 64 240 women from the Copenhagen General Population Study and the Copenhagen City Heart Study combined. Hazard ratio (solid line) and 95% confidence interval (dashed lines) from age and study adjusted Cox regression using restricted cubic splines. The concentration of HDL cholesterol associated with lowest mortality was used as reference. The light blue area indicates the distribution of HDL cholesterol concentrations in men and women. CI, confidence interval; HDL, high-density lipoprotein.

    HDL might not be as good as we think...

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